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    L-Theanine molecular structure

    L-Theanine Stats & Data

    Theanine N5-ethyl-l-glutamine Gamma-glutamylethylamide L-gamma-glutamylethylamide
    NPS DataHub
    MW174.2
    FormulaC7H14N2O3
    CAS3081-61-6
    IUPAC(2''S'')-2-Ammonio-5-(ethylamino)-5-oxopentanoate
    SMILESCCNC(=O)CCC(N)C(=O)[O-].[H+]
    InChIKeyDATAGRPVKZEWHA-YFKPBYRVSA-N
    Chemical Class Amino acid
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank

    Description

    Theanine, a precursor of ethylamine, is found in green tea. It is under investigation in clinical trial NCT00291070 (Effects of L-Theanine in Boys With ADHD).

    Toxicity

    PsychonautWiki

    Theanine is non-addictive, is not known to cause brain damage, and has an extremely low toxicity relative to dose. There are relatively few physical side effects associated with acute theanine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences. It is strongly recommended that one use harm reduction practices when using this substance.

    Effect Profile

    Curated + 4 Reports
    Stimulant 5.9

    Strong focus with mild euphoria, low stimulation and anxiety/jitters

    Stimulation / Energy×3
    3
    Euphoria / Mood Lift×2
    5
    Focus / Productivity×2
    10
    Anxiety / Jitters×1
    2

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Experience Report Analysis

    Erowid
    12 Reports
    4 Single-substance
    2001–2020 Date Range
    11 With Age Data
    3 Effects Detected

    Demographics

    Gender Distribution

    Too few reports for a chart: gender is known from 12 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Male 11 of 12
    • Female 1 of 12

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 4 experience reports (4 single-substance Erowid)

    4 Reports
    3 Effects Detected
    2 Positive
    1 Adverse
    0 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Too few reports for bars: these effects come from 4 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    Positive Effects 2

    Euphoria 3 of 4 70%
    Stimulation 3 of 4 70%

    Adverse Effects 1

    Anxiety 3 of 4 70%

    Also reported in combinations. In the 8 L-Theanine reports where another drug was taken too, 1 mentions hospital, emergency services or an overdose, 0 a seizure and 0 psychosis (too few reports for percentages). In the 4 single-substance reports: 0, 0 and 0. These are not in the figures above: they cannot be put down to L-Theanine alone, and a mention is not always something that happened to the writer.

    Real-World Dose Distribution

    Erowid

    From 439 of 442 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Oral (n=431)

    Median: 400.0mg 25th: 400.0mg 75th: 400.0mg 90th: 500.0mg

    Common Combinations

    Most co-occurring substances, as a share of all 12 reports filed under L-Theanine

    Too few reports for bars: these combinations come from 12 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Caffeine 4 of 12

    Form / Preparation

    Most common forms and preparations, as a share of the 5 reports that give one

    Too few reports for bars: these forms come from 5 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Powder / Crystals 3 of 5
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