First Beautiful Foray with Isoproscaline Substance: Isoproscaline, 45mg (weighed out) Set & Setting: My condominium on a Saturday evening. Feeling generally positive and good.
Isoproscaline
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Ip
Summary
A analogue of mescaline, and more closely related to proscaline.
Perspectives
“Starts slowly. I develop some queasiness, turning into nausea. Feels good to lie down and let go, but the uneasiness remains. Just beginning to break through in 2 hours. But the occasional sense of relief, the breaking into the open, were transient as new sources of discomfort were always being dredged up. Then for some reason I chose to dance. Letting go to dancing, a marvelous ecstatic experience, flowing with and being the energy, body feeling completely free. Noticing how this letting go got one completely out of the feeling of unease, as though attention simply needs to be put elsewhere. Comedown was very slow, gentle, euphoric; a very signicant experience. Sleep that night was impossible, but felt good to simply release to the feelings. Keeping mind still, no thinking, just allowing feelings to go where they wished, became more and more ecstatic. Tremendous feeling of confidence in life and the life process. Complete sense of resolution.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-50mg | 50-60mg | 60-80mg | 80mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 1-3 hrs | 10-20 hrs | 10-20 hrs |
Effect Profile
3 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.1
Light+
3/10
Mild visuals with low body load and headspace
Visual Intensity
×3
4
color enhancement
brightened colour
visual distortions
Headspace Depth
×3
2
confusion
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
3
muscle tension
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Effects
Aggregated from 3 single-substance Erowid experience reports; 1 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 3 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 2
3 of 3
–
3 of 3
–
Adverse Effects 0
Combinations
Cross-Check Isoproscaline with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 4 reports 1 positive 1 neutral 2 cautionary visit
1. Subject Information 1.1 Usage Details Substance: Isoproscaline Date of use: 2025/9/26 Dose: ~80 mg Purity: 97% (HPLC) Route of administration: Mostly oral, with a smaller portion taken intranasally 1.2 User Information Age: 22 Sex (Assigned at Birth): Male Height: 176 cm Weight: 49 kg Background / medical history: H...
First Trial With Isoproscaline Isoproscaline*HCl Β 4-isopropoxy-3,5-dimethoxyphenethylamine hydrochloride Dosage: 80 mg Set: starting at a train station on the way home, then at home, mostly in front of computer, listening to music. Setting: currently difficult situation in life. Earlier, some conflict with my dad.
More than 20 years ago perusing the second section of Shulgin's PIHKAL my eyes fell on #92; beguiled by the two glowing accounts furnished by way of illustrating the 'color and complexity of IP" and above all by Sasha's declaration that it has "proven to be a completely fascinating phenethylamine" a mild, if enduring o...
PiHKAL / TiHKAL
PiHKAL #92: IP
“Starts slowly. I develop some queasiness, turning into nausea. Feels good to lie down and let go, but the uneasiness remains. Just beginning to break through in 2 hours. But the occasional sense of relief, the breaking into the open, were transient as new sources of discomfort were always being dredged up. Then for some reason I chose to dance. Letting go to dancing, a marvelous ecstatic experience, flowing with and being the energy, body feeling completely free. Noticing how this letting go got one completely out of the feeling of unease, as though attention simply needs to be put elsewhere. Comedown was very slow, gentle, euphoric; a very signicant experience. Sleep that night was impossible, but felt good to simply release to the feelings. Keeping mind still, no thinking, just allowing feelings to go where they wished, became more and more ecstatic. Tremendous feeling of confidence in life and the life process. Complete sense of resolution.”
Isoproscaline's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Isoproscaline there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
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Import this file as custom substances
and you get "Isoproscaline (Substance Search)" with every
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Name
Isoproscaline
Unit
mg
Description
Isoproscaline Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 30 Β· light 40-50 Β· common 50-60 Β· strong 60-80 Β· heavy 80+ Oral duration: onset 1-3h Β· peak 10-20h Β· total 10-20h Β· after-effects 1-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 55 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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