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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Isophenmetrazine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • classified Tentative
    • classified Research-chemical

    Stimulant Research-chemical

    Summary TripSit

    Rare and little known analogue of phenmetrazine, which is slightly more potent than other analogues. Probably a stimulating, appetite supressing drug with high addiction potential. Potentially a dopamine and/or norepinephrine releasing agent.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 2-5mg 5-15mg 20-40mg 40mg+
    Oral 5-10mg 10-20mg 20-50mg 50mg+
    Light Common Strong Heavy
    Sources

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects
    Oral 15-30 min 3-5 hrs 1-6 hrs

    Effect Profile

    class estimate

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 3 other substances of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 3.8
    Moderate 4/10

    Moderate stimulation and euphoria with strong anxiety/jitters

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    6
    euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate vasoconstriction
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Isophenmetrazine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Isophenmetrazine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Isophenmetrazine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Isophenmetrazine
    Unit
    mg
    Description 
    Isophenmetrazine
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): light 2-5 · common 5-15 · strong 20-40 · heavy 40+
Oral dose (mg): light 5-10 · common 10-20 · strong 20-50 · heavy 50+

Insufflated duration: after-effects 1-6h
Oral duration: onset 15-30m · peak 3-5h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 10 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.