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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Hexedrone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Aliases: Hex, Macp, Alpha-methylamino-caprophenone

    Stimulant Research-chemical

    Summary dose.wiki TripSit PsychonautWiki

    Hexedrone is a synthetic stimulant cathinone with limited research and an extremely short history of human use. It is less potent than pentedrone and N-ethylhexedrone. Users should exercise extreme caution due to insufficient toxicology data and potential cardiovascular strain.

    Dose Information dose.wiki PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-70mg 70-100mg 100-125mg 125mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-30 min 1-2 hrs 1-2 hrs 1-12 hrs 1-4 hrs
    Insufflated 5-15 min 30-90 min 1-2 hrs 1-12 hrs 1-4 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.1
    Moderate+ 5/10

    Strong focus with strong anxiety/jitters, moderate euphoria, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement analysis enhancement thought acceleration motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 7d Baseline ~14d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check Hexedrone with another substance

    Hexedrone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 TripSit 📖 PsychonautWiki
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has Hexedrone, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "Hexedrone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Duration (reference) 
    Hexedrone: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)


Insufflated duration: onset 5-15m · peak 0.5-1.5h · offset 1-2h · total 1-4h · after-effects 1-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Ranges are harm-reduction guidance, not a prescription.