Grapefruit
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
Aliases: Pomelo, Forbidden fruit
Summary
Bergamottin and 6',7'-dihydroxybergamottin in grapefruit irreversibly inactivate intestinal CYP3A4 via mechanism-based covalent binding, reducing enzyme abundance by 50-70% after a single 200 ml serving. Full resynthesis takes 24-72 hours, meaning timing separation of grapefruit and medication does not prevent interactions. Parallel inhibition of intestinal P-glycoprotein raises systemic exposure to many substrates, while OATP1A2 blockade can paradoxically lower absorption of drugs like fexofenadine.
Dose Information
| ROA | Light |
|---|---|
| Oral | 100-200ml |
Sources
Oral
Dose ladder — Light: DrugsPROOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 30 min | 24 hrs | 25.25-26 hrs |
Tolerance
Tolerance Decay
Effects
Effect glossary — · full glossary
- Bitter-sweet citrus flavor
Helpful Links
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The PsychonautWiki Journal logging app doesn't include every substance. To track Grapefruit there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Grapefruit Source: SubstanceSearch (substancesearch.com) Oral dose (ml): threshold 50 · light 100-200 Oral duration: onset 15-30m · come-up 0.5-1h · peak 30m · offset 24h · total 25.25-26h · after-effects 24-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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