Gaboxadol has been a compound I've been eager to try since the vatic psychopharmacological ectomorph Hamilton Morris wrote about in Harper's. Oceanic sleep has been a dream of mine since I was a child; I've been tormented by night tremors for over a decade, and bouts of insomnia have been recurrent throughout my teenag...
Gaboxadol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 27 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 27 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Thip, Ov101, Mk-0928, Lu-2-030, Lu-02-030
Summary
Gaboxadol (THIP) is a direct-acting GABA-A receptor agonist developed by Lundbeck and Merck as an experimental sleep aid. Clinical trials were discontinued in 2007 due to narrow therapeutic index and psychiatric side effects at effective doses. Unlike benzodiazepines, it acts as an orthosteric agonist at the GABA binding site with preferential activity at extrasynaptic Ξ΄ subunit-containing receptors.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-15mg | 15-30mg | 30-45mg | 45mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — dose.wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-60 min | 30-60 min | 1-3 hrs | 2-4 hrs | 3.75-9 hrs |
Tolerance
Build-up
develops over 1β4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.
No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines Β· Alcohol and Drug Foundation: GHB Β· FDA 2020: benzodiazepine boxed warning Β· FDA 2019: gabapentinoids and breathing Β· NHS: alcohol use disorder
Cross-Tolerances
Benzodiazepines (GABA-A positive allosteric modulators)
Barbiturates
Z-drugs (zolpidem, zopiclone)
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Combinations
Cross-Check Gaboxadol with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 2 neutral visit
Gaboxadol is a structural derivative of the alkaloid Muscimol, a constituent of the pharmacological cocktail in the Amanita muscaria species of mushroom. A powerful, yet non-reinforcing hypnotic agent (unlike benzodiazepines, which are often prescribed for insomnia), Gaboxadol never found its way into any pharmaceutica...
Gaboxadol's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Gaboxadol, but its built-in data can be thinner than ours. Importing this file adds a separate "Gaboxadol (Substance Search)" custom substance with our dose ranges and durations, so you can log against whichever you prefer. It leaves tolerance out on purpose, for the reason given under Tolerance above.
⬇ Download import file
Import this file as custom substances
and you get "Gaboxadol (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Gaboxadol? Let us know. Reports are reviewed by moderators — this is not posted publicly.