DMNPC
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
DMNPC is a piperidine-based stimulant and research chemical. It blocks voltage-gated sodium channels similar to cocaine, producing local anesthesia and potential cardiac conduction effects, and acts as a monoamine reuptake inhibitor with binding affinities of approximately 7.6 nM at SERT, 21 nM at DAT, and 34 nM at NET. These figures make it roughly 2.5 times more potent than cocaine at DAT while retaining SSRI-level SERT affinity. Users report severe mucosal irritation with intranasal use and caustic effects when administered intravenously.
Dose Information
| ROA | Threshold |
|---|---|
| Oral | 5mg |
| Insufflated | 5mg |
| Intravenous | 2mg |
| Vaporized / Smoked | 5mg |
| Rectal | 5mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Oral
Dose ladder — DrugsPROInsufflated
Dose ladder — DrugsPROIntravenous
Dose ladder — DrugsPROVaporized / Smoked
Dose ladder — DrugsPRORectal
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 15-30 min | 30-90 min | 1-2 hrs | 2-4.5 hrs |
| Insufflated | 5-10 min | 10-20 min | 30-90 min | 1-2 hrs | 1.75-4 hrs |
| Intravenous | 1-5 min | 5-10 min | 10-45 min | 1-2 hrs | 1.27-3 hrs |
| Vaporized / Smoked | 1-5 min | 5-10 min | 10-45 min | 1-2 hrs | 1.27-3 hrs |
| Rectal | 10-20 min | 15-30 min | 30-90 min | 1-2 hrs | 1.92-4.33 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, mild stimulation and focus
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Effect glossary — · full glossary
- Visual and auditory hallucinations
Combinations
Cross-Check DMNPC with another substanceHelpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track DMNPC there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
DMNPC Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 5 Insufflated dose (mg): threshold 5 Intravenous dose (mg): threshold 2 Vaporized / Smoked dose (mg): threshold 5 Rectal dose (mg): threshold 5 Oral duration: onset 15-30m · come-up 15-30m · peak 0.5-1.5h · offset 1-2h · total 2-4.5h · after-effects 1-6h Insufflated duration: onset 5-10m · come-up 10-20m · peak 0.5-1.5h · offset 1-2h · total 1.75-4h · after-effects 1-6h Intravenous duration: onset 1-5m · come-up 5-10m · peak 10-45m · offset 1-2h · total 1.27-3h · after-effects 1-6h Vaporized / Smoked duration: onset 1-5m · come-up 5-10m · peak 10-45m · offset 1-2h · total 1.27-3h · after-effects 1-6h Rectal duration: onset 10-20m · come-up 15-30m · peak 0.5-1.5h · offset 1-2h · total 1.92-4.33h · after-effects 1-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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