Cyproheptadine Encyclopedic

Encyclopedic

Typical encyclopedia coverage. Cross-reference for important decisions.

2 corroborating sources

1 ROA with full dose ladder

duration data present

PubChem toxicity data

dose data not in PW/TripSit (unverifiable)

Aliases: Reactin, Apeplus, Biohept, Periatin, Periactin

Summary dose.wiki

For serotonin syndrome management: administer a 12 mg oral loading dose, then 2 mg every 2 hours until clinical improvement (max 32 mg/24 hours); thereafter give 4-8 mg every 6 hours as needed. Monitor for over-sedation, urinary retention, delirium, and hepatic enzymes in prolonged courses. May interfere with hemostasis and prolong bleeding time.

Dose Information Drugs.Wiki

Dose basis. Ranges aligned to therapeutic tablet strengths (4 mg) and typical single-dose sedation reports; do not exceed 32 mg in any 24-hour period without medical oversight. Community reporting + label-style dosing context; not a target for recreation. (Dose figures and this note are from Drugs.Wiki.)

ROA	Light	Common	Strong	Heavy
Oral	4-8mg	8-12mg	16-20mg	24-32mg

Light Common Strong Heavy

Sources

Oral

Dose ladder — Drugs.Wiki

Onset, Duration & After-effects dose.wiki Drugs.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	30-60 min	1-3 hrs	2-6 hrs	2-4 hrs	24 hrs	5.5-14 hrs

Tolerance

Build-up develops over 1–4 weeks of regular use

Reset days to weeks depending on duration of use

Tolerance Decay

Half tolerance 3d Baseline ~14d

Users commonly report tolerance to the sedative effect developing over several days of continuous use and partial reversal over weeks after cessation; robust quantitative data are lacking.

Effects dose.wiki

Positive

Negative

Neutral

Positive

Negative

Neutral

Visual and audio distortions

Pill Identifiers

9 known pill identifiers on record — view imprints, colors, shapes, and images

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Cyproheptadine's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

💊 Pill Identifier 📖 dose.wiki

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track Cyproheptadine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "Cyproheptadine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

Cyproheptadine

Unit

Description

Cyproheptadine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2-4 · light 4-8 · common 8-12 · strong 16-20 · heavy 24-32

Oral duration: onset 0.5-1h · come-up 1-3h · peak 2-6h · offset 2-4h · total 5.5-14h · after-effects 24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 10 mg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Cyproheptadine? Let us know. Reports are reviewed by moderators — this is not posted publicly.

Cyproheptadine Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 2 corroborating sources 1 ROA with full dose ladder duration data present PubChem toxicity data dose data not in PW/TripSit (unverifiable)