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    Cyclizine Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • partial dose data
    • duration data present

    Summary TripSit

    First generation antihistamine and anticholinergic drug used to combat nausea and vomiting. Causes drowsiness. Like most antihistamines in high doses it induces delirium and vivid realistic hallucinations.

    Dose Information dose.wiki TripSit

    ROA Common
    Oral 25-50mg
    Common
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects
    Oral 10-30 min 4-8 hrs 14 hrs

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects Erowid

    Aggregated from 8 single-substance Erowid experience reports; 4 Erowid reports where another drug was taken too are left out

    Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

    Too few reports for bars: these effects come from 8 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    Positive Effects 2

    3 of 8 –
    3 of 8 –

    Adverse Effects 2

    6 of 8 –
    3 of 8 –

    Also reported in combinations. In the 4 Cyclizine reports where another drug was taken too, 1 mentions hospital, emergency services or an overdose, 0 a seizure and 1 psychosis (too few reports for percentages). In the 8 single-substance reports: 2, 0 and 0. These are not in the figures above: they cannot be put down to Cyclizine alone, and a mention is not always something that happened to the writer.

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 8 reports 1 positive 2 neutral 5 cautionary visit
    Did They Mix Datura in this Drug? positive exp #64775

    At the time of the consumption, I was serving in the norwegian armed forces, where I had the time to do stuff like this. And actually, it was a perfect environment. Me and a friend had been at the drug store earlier that day to get marezine, I don't actually know where we got this idea, but we did.

    tojal · Cyclizine (Marezine) · 12 tablets oral
    Spiders and Mystical Wallpaper cautionary exp #61347

    I found a bottle of cyclizine in my medical box that my ex had left behind when she left and I liked the sound of the name so I decided to look it up. Time: 10:22 pm I read on a website that the effects didn’t kick in for a couple of hours so I decided to pass the time with some porn and masturbation as I have found ma...

    Flash · 500 mg oral
    Crazyness Ensues cautionary exp #62770

    Being just a youngun, I (stupidly?) took some older friends advice and ate 8-10 tablets of Marezine one fine summer afternoon. They told me all about these wonderful acid like side effects, except one small difference, being that 'whatever I imagine, will come to life in 3D.' I thought, 'Sure, right.' I started out sit...

    Lil Tripper · Cyclizine (Marezine)
    Complete Mutiny (Literally) neutral exp #5776

    I have never really been a big fan of marijuana or alcohol (definitely a user, just not a big fan). I'm more into the instant gratification type of drugs, ie. MDMA, LSD, pain killers. I don't have to worry about smoking or filling my stomach with liquids I'm gonna puke up anyway.

    Mike Rakhabit · Cyclizine (Marezine) · 800 mg oral
    Not Fun cautionary exp #108573

    It was a Saturday night in the late 1980s and my friends were having a little party. All of them were on LSD but me and the good friend I came with. We showed up late and all the hits gone. We heard of Marezine from other friends who took about 5 pills and reported that it was a bit weird.

    JFC
    Sick, with Visions cautionary exp #45634

    I've tried just about every common drug there is to try and have had a positive experience with the majority of them at least for my first time. One of the few exceptions to this that stands out in my mind is your basic motion-sickness 'trip'.

    Donetomuch · Cyclizine (Marezine) · 12 tablets oral
    Tiny People neutral exp #13685

    I’ve done diphenhydramine, dimenhydrinate, meclizine, and cyclizine. I first decided to report on cyclizine. However, I’ll refer to these other substances briefly. Firstly, I caution against taking any of these substances in high amounts. Too much can cause a scary, near death like experience.

    agent23 · 600 mg oral
    Anti-Sickness Hell cautionary exp #50040

    I was recently rushed to hospital with suspected Meningitis. I had a viral infection with all the same symptoms so they kept me in for a few days under obs. I’m 22, eat healthily, don’t drink smoke or do drugs, and generally I’m really fit and strong I go gym regularly, and to be this ill was very concerning for the do...

    Anonymous · IV
    Bluelight 1 thread 1 neutral visit
    Cyclizine Hydrochloride Wow neutral

    My trip into a delirious state Cyclizine hydro total dose was 350 mg's i read some people took like 600 mg's wow gl on who ever tries that. the time was about 10pm i was playing some games on my xbox and i remembered about these pills i had found lying in my friends flat and decided to google there effects.

    350 mg mentioned in the thread; auto-extracted, unverified
    →

    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Cyclizine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Cyclizine
    Unit
    mg
    Description
    Cyclizine
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): common 25-50
    
    Oral duration: onset 10-30m · peak 4-8h · after-effects 14h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.