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    Creatine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • toxicity data (PsychonautWiki, PubChem)

    Aliases: N-amidinosarcosine, Methylguanidoacetic acid, N-carbamimidoyl-n-methylglycine

    Stimulant Nootropic Supplement

    Summary dose.wiki PsychonautWiki

    Creatine is a naturally occurring amino acid and one of the most well-researched dietary supplements. While generally considered safe at recommended doses (3-5 g/day maintenance), proper hydration is essential to prevent cramping and gastrointestinal distress. Individuals with pre-existing kidney disease should consult a healthcare provider before use.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 1-5g 5-10g 10-20g 20g+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.4
    Strong 6/10

    Strong focus with moderate stimulation, low euphoria and anxiety/jitters

    Stimulation / Energy ×3
    7
    physical stimulation stimulation stamina enhancement
    Euphoria / Mood Lift ×2
    2
    motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement analysis enhancement memory enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Creatine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes Creatine, but its built-in data can be thinner than ours. Importing this file adds a separate "Creatine (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "Creatine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.