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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Coluracetam Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 4 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Aliases: Bci-540, Mkc-231

    Stimulant Nootropic Research-chemical

    Summary PsychonautWiki

    Coluracetam (BCI-540; formerly MKC-231) is a nootropic belonging to the racetam family of drugs. It was originally developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug had failed to reach the endpoints in its clinical trials, it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Oral 3-5mg 5-10mg 10-20mg 20mg+
    Sublingual 2-5mg 5-10mg 10mg+ -
    Insufflated 2-5mg 5-10mg 10-20mg 20mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki, TripSit

    Sublingual

    Dose ladder — dose.wiki, TripSit

    Insufflated

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-30 min 1-2 hrs 3-5 hrs 1-6 hrs 3-6 hrs
    Sublingual 1-5 min 1-2 hrs 3-5 hrs 1-6 hrs 3-6 hrs
    Insufflated 0-6 min - - 1-4 hrs 3-6 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.8
    Strong+ 7/10

    Strong focus and stimulation with low euphoria and anxiety/jitters

    Stimulation / Energy ×3
    8
    stimulation stamina enhancement wakefulness mild stimulation
    Euphoria / Mood Lift ×2
    2
    motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement analysis enhancement memory enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Coluracetam
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Tolerance patterns are based on community reports (no controlled human data). Many users report diminishing returns with daily use and prefer spacing doses to a few days per week. Cross‑tolerance between racetams is plausible but unquantified.

    Cross-Tolerances

    Other racetams

    Effects dose.wiki TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral
    Coluracetam's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has Coluracetam, but its built-in entry only covers Insufflated, Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "Coluracetam (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Custom Unit doses
    • Sublingualcommon ~ 7.5 mg
    Dose & duration (reference) 
    Coluracetam: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (mg): light 2-5 · common 5-10 · strong 10+

Sublingual duration: onset 1-5m · peak 1-2h · offset 3-5h · total 3-6h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.