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    Clonidine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • toxicity data (PsychonautWiki, PubChem)

    Aliases: Kapvay, Dixarit, Catapres, Haemiton, Duraclon

    Summary PsychonautWiki

    Clonidine (known by the trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a depressant substance of the arylaminoimidazoline class. It is primarily used to treat high blood pressure, but can also be used for a variety of conditions that include attention deficit hyperactivity disorder, anxiety disorders, tic disorders, substance withdrawal, migraine, diarrhea, and certain pain conditions.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 50-75μg 75-100μg 100-300μg 300μg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 12-48 min 60-90 min 6-8 hrs 1-4 hrs 8-16 hrs

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects Erowid

    Aggregated from 11 single-substance Erowid experience reports; 14 Erowid reports where another drug was taken too are left out

    Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

    Too few reports for bars: these effects come from 11 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    Positive Effects 1

    4 of 11 –

    Adverse Effects 0

    Also reported in combinations. In the 14 Clonidine reports where another drug was taken too, 2 mention hospital, emergency services or an overdose, 1 a seizure and 0 psychosis (too few reports for percentages). In the 11 single-substance reports: 0, 0 and 1. These are not in the figures above: they cannot be put down to Clonidine alone, and a mention is not always something that happened to the writer.

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 8 reports 3 neutral 5 cautionary visit
    Abuse Potential? cautionary exp #53336

    Recently reports have been emerging in medical journals of opiate addicts abusing clonidine to get a opiate like high. I also found a government website that lists clonidine as a emerging drug of abuse and found reports that clonidine is being sold on the streets of new york.

    Student
    Zoned Out at the Mall cautionary exp #42480

    I received 25 tablets of Clonidine from a friend, in payback of $25 he owed me. I and a friend went to pick it up, and we went with his sister to the mall to get her nails (??) done. On the way to the mall, me and my friend both dropped 2 of these tablets each.

    Anonymous · 1.2 mg oral / smoked
    Opiate With Druel... cautionary exp #61132

    After being an every day user of hero wan... for about 4 or 5 months, i decided one day to quit cold turkey (mind you, i was not shooting it, only snorting it, but i was doing anywhere from 6 to 10 bags a day, which is ALOT, enough to easily OD a non-user, or even an unexperienced user with slight tolerance) so ive fel...

    chill · repeated insufflated / repeated
    Effective, Without Screwing Up My Head cautionary exp #26506

    I am a smoker, and have been since I was 14..that was in 1987. I have tried nearly everything there is to quit. Clonidine worked for me...at least until I stopped taking it. I was prescribed Clonidine twice in my life. When I was 21 my doctor prescribed it as a smoking cessation aid.

    Sinnlos · oral
    Riding the Wave neutral exp #22952

    I have had a lot of history of using opiates, primarily vicodin, oxycontin, percocet, and other commonly prescribed narcotic painkillers. I have also had much experience with the feelings associated with the withdrawal symptoms which I almost 90% of the time will be completely aware of whenever I cease to take my pills...

    V-Man57 · transdermal / oral / oral / oral
    The Rhythm of Ticks neutral exp #40371

    I used to take Clonidine as a supressor for Tourette Syndrome. I took 2 pills each night before going to bed for a few years straight. Basically, what it did to me was it would slow my heart rate and make me more tired and lazy, this had a positive impact on my Tourette ticks, but I was almost always tired.

    Rob · oral / smoked
    Not So Fun neutral exp #87245

    This was a very dumb mistake on my part, as I should have looked these pills up on the internet before taking them to make sure of what they were. I received 15 pills from a guy telling me they were Klonopin.

    sicory
    Augmenting Insomnia cautionary exp #28349

    I was 15 when my doctor prescribed me to Clonidine. I have several neurosis and psychosis (one of which is Insomnia). I had gone off the pills for a while to try to work out my problems without pharmeceutical help (with next to no success).

    Lab Munkee · oral
    Bluelight 1 thread 1 cautionary visit
    Anaphylactic Reaction To Clonidine Newbie Clonidine 1 Mgs cautionary

    Out of all the drugs it's possible to be allergic to; Clonidine is probably one of the lowest things I ever expect to have problems with. Two days ago (Friday night, Saturday morning) at 2:00 AM, I decided it was probably a good idea to get some sleep.

    1 mg mentioned in the thread; auto-extracted, unverified

    Pill Identifiers

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    Helpful Links

    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes Clonidine, but its built-in data can be thinner than ours. Importing this file adds a separate "Clonidine (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "Clonidine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.