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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Clomethiazole Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • partial dose data
    • duration data present
    • classified Tentative
    • classified Research-chemical

    Depressant Research-chemical

    Summary TripSit

    Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.

    Dose Information dose.wiki TripSit

    ROA Light Common Heavy
    Oral 100-150mg 150-200mg 200mg+
    Light Common Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 15-40 min 5-8 hrs 1-16 hrs 5-8 hrs

    Effects

    Positive
    Neutral
    Positive
    Negative
    Negative
    Neutral

    Combinations

    Cross-Check Clomethiazole with another substance

    Clomethiazole's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Clomethiazole there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Clomethiazole
    Unit
    mg
    Description 
    Clomethiazole
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 100 · light 100-150 · common 150-200 · heavy 200+

Oral duration: onset 15-40m · peak 5-8h · total 5-8h · after-effects 1-16h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 175 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.