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    Clomethiazole

    Categories

    depressant research-chemical habit-forming tentative

    Clomethiazole structure

    Summary

    Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.

    ⚠️ WARNING: The normal amount in capsules is 192mg's. Treat this more as a barbiturate than a benzodiazepine, as the toxicology for this substance is rather lacking.

    Dose Information

    Onset, Duration & After-effects

    • Onset: 15-40 minutes
    • Duration: 5-8 hours
    • After-effects: 1-16 hours

    Effects