Chlorpheniramine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Piriton, Demazin, Teldrin, Allerest
Summary
Chlorpheniramine is a first-generation antihistamine used for allergy relief. At therapeutic doses it causes drowsiness and anticholinergic effects including dry mouth, blurred vision, and urinary retention. High doses can cause delirium with realistic hallucinations.
Dose Information
Dose basis. Common is exactly the FDA over-the-counter label dose: 4 mg every 4–6 hours, with a hard maximum of 24 mg in 24 hours (extended-release: 12 mg every 12 hours, same 24 mg ceiling). Strong and Heavy are above the labelled per-dose amount and are shown as a warning boundary, not as targets — chlorpheniramine is anticholinergic, so higher doses bring dry mouth, racing heart, confusion and eventually delirium rather than a stronger effect, and its long half-life means repeat doses stack.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-4mg | 4mg | 6-10mg | 10mg+ |
Sources· no ladder identified
Oral
Dose ladder — source not identifiedOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 20-40 min | 1-3 hrs | 1-2 hrs | 4-6 hrs |
Tolerance
Tolerance Decay
With repeated daily use, subjective sedation may diminish over several days, but anticholinergic cognitive/urinary effects persist; cross-tolerance with other first-generation antihistamines is likely anecdotally but not well-quantified.
Effects
Effect glossary — · full glossary
- Visual and audio distortions
Combinations
Cross-Check Chlorpheniramine with another substancePill Identifiers
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Chlorpheniramine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Chlorpheniramine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 1-2 · light 2-4 · common 4 · strong 6-10 · heavy 10+ Oral duration: onset 0.5-1h · come-up 20-40m · peak 1-3h · offset 1-2h · total 4-6h · after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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