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    ⚠ Barbiturates have a narrow therapeutic window and high overdose risk. Combining with alcohol or other depressants can be fatal.

    Barbital Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • partial dose data
    • duration data present

    Summary TripSit

    The first commercially available barbiturate. Was used commonly as a sleeping aid until the 1950s.

    Dose Information dose.wiki TripSit

    ROA Common
    Oral 650-970mg
    Common
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak Total
    Oral 15-30 min 6-12 hrs 6-12 hrs

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually. With barbiturates, you get used to the effects much more than to a dangerous dose, so the gap between a dose that works and one that kills shrinks the more you use. Stopping suddenly after regular use can cause convulsions and delirium.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder · Phenobarbital label: drug abuse and dependence

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral
    →

    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Barbital there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Barbital
    Unit
    mg
    Description
    Barbital
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): common 650-970
    
    Oral duration: onset 15-30m · peak 6-12h · total 6-12h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 810 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.