Beta test rollout. This site is in community QA — please send feature requests, bug reports and data corrections on the Feedback page or on GitHub.

Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Avizafone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Pro-diazepam

    Depressant Research-chemical

    Summary dose.wiki

    Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues.

    Dose Information Drugs.Wiki

    Dose basis. Oral: Ranges are aggregated from community reports; no peer‑reviewed human dosing monograph exists. Oral avizafone is a prodrug to diazepam. Due to molecular weight differences and variable conversion, mg-for-mg potency is expected to be lower than diazepam. Start low and titrate cautiously; see notes and interactions for factors that increase potency (e.g., CYP2C19/CYP3A4 inhibition). Anecdotal reports indicate substantial between‑person variability. Intramuscular: Intended clinical route in legacy research. Use of non‑sterile solvents or technique risks abscess, cellulitis, and systemic infection. Water‑soluble avizafone does not require propylene glycol; avoid improvised PG/EtOH injectates. If someone chooses to IM despite risks, use new sterile equipment, bacteriostatic/sterile water, rotate sites, and never share supplies. Community reports only; not a recommendation. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-30mg 30-60mg 60mg+
    Intramuscular 5-10mg 10-20mg 20-30mg 30mg+
    Insufflated 5-10mg 10-15mg 15-20mg 20mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Intramuscular

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-60 min - 3-8 hrs 12-48 hrs 6-24 hrs
    Intramuscular 5-15 min 1-2 hrs 3-6 hrs 24 hrs 4.08-8.25 hrs
    Insufflated 1-10 min - 3-8 hrs 12-48 hrs 6-24 hrs

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Cross-Tolerances

    diazepam
    other benzodiazepines
    non-selective GABA_A positive modulators

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check Avizafone with another substance

    Avizafone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Avizafone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Avizafone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Avizafone
    Unit
    mg
    Description 
    Avizafone
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2-5 · light 5-15 · common 15-30 · strong 30-60 · heavy 60+
Intramuscular dose (mg): threshold 2.5 · light 5-10 · common 10-20 · strong 20-30 · heavy 30+
Insufflated dose (mg): threshold 2-5 · light 5-10 · common 10-15 · strong 15-20 · heavy 20+

Oral duration: onset 0.25-1h · offset 3-8h · total 6-24h · after-effects 12-48h
Intramuscular duration: onset 5-15m · peak 1-2h · offset 3-6h · total 4.08-8.25h · after-effects 24h
Insufflated duration: onset 1-10m · offset 3-8h · total 6-24h · after-effects 12-48h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 22.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.