Beta test rollout. This site is in community QA — please send feature requests, bug reports and data corrections on the Feedback page or on GitHub.

Home
    Disclaimer

    Apomorphine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 5 ROAs with full dose ladders
    • duration data present
    • PubChem toxicity data

    Aliases: Apokyn, Onapgo, Apo-go, Ixense, Uprima

    Stimulant

    Summary dose.wiki

    Apomorphine is primarily used to treat acute hypomobility episodes in advanced Parkinson's disease. Despite its name, it does not contain morphine and does not bind to opioid receptors. Nausea is extremely common; antiemetic pretreatment with trimethobenzamide or domperidone is typically required.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Subcutaneous 1-2mg 2-4mg 4-8mg 8mg+
    Sublingual 10mg - - -
    Oral 2-5mg 5-10mg 10-15mg 15mg+
    Insufflated 0.5-1mg 1-2mg 2-4mg 4mg+
    Smoked 0.5-1mg 1-2mg 2-4mg 4mg+
    Intravenous 1-2mg 2-4mg 4-8mg 8mg+
    Light Common Strong Heavy
    Sources

    Subcutaneous

    Dose ladder — PsychonautWiki

    Sublingual

    Dose ladder — DrugsPRO

    Oral

    Dose ladder — PsychonautWiki

    Insufflated

    Dose ladder — PsychonautWiki

    Smoked

    Dose ladder — PsychonautWiki

    Intravenous

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Subcutaneous 5-15 min 1-2 hrs 1-2 hrs 30-60 min 1-12 hrs 1-2 hrs
    Sublingual 10-30 min 15-30 min 30-90 min 30-60 min - 1.42-3.5 hrs
    Oral 15-30 min 20-40 min 1-2 hrs 30-60 min 1-12 hrs 2-4 hrs
    Insufflated 5-15 min 20-40 min 1-2 hrs 30-60 min 1-12 hrs 3-6 hrs
    Smoked 1-5 min 5-15 min 15-30 min 30-60 min 1-12 hrs 1-2 hrs
    Intravenous 1-5 min 5-15 min 15-30 min 30-60 min 1-12 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.2
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation, mild euphoria, low focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    2
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    8
    anxiety increased heart rate vasoconstriction
    Based on reports from:
    PsychonautWiki Apomorphine
    View methodology →

    Tolerance

    Cross-Tolerances

    Other dopamine agonists (e.g., pramipexole, ropinirole)

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Apomorphine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has Apomorphine, but its built-in entry only covers Insufflated, Intravenous, Oral, Smoked, Subcutaneous. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "Apomorphine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Dose & duration (reference) 
    Apomorphine: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (mg): light 10

Subcutaneous duration: onset 5-15m · come-up 1-2h · peak 1-2h · offset 0.5-1h · total 1-2h · after-effects 1-12h
Sublingual duration: onset 10-30m · come-up 15-30m · peak 0.5-1.5h · offset 0.5-1h · total 1.42-3.5h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.