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    APICA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • 27 combo interactions documented

    Cannabinoid

    Summary PsychonautWiki

    APICA (also known as SDB-001, and 2NE1) is a novel synthetic cannabinoid that produces modified cannabis-like effects when administered. It has been shown to act as a potent agonist for the CB1 and CB2 cannabinoid receptors.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Smoked 0.5-1.5mg 1.5-2mg 2-4mg 4mg+
    Light Common Strong Heavy
    Sources

    Smoked

    Dose ladder — dose.wiki, PsychonautWiki

    Onset, Duration & After-effects PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Smoked <1-2 min 12-30 min 6-12 min 12-36 min 18-44 min

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 21d Baseline ~28d

    Effects PsychonautWiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • Visual sharpening or mild pseudo-hallucinations

    Combinations

    Cross-Check APICA with another substance

    APICA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes APICA, but its built-in data can be thinner than ours. Importing this file adds a separate "APICA (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "APICA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.