As I mentioned in a previous post about having a vial of Amobarbital, I was brave enough to go ahead and use it, after having an awful experience with Secobarbital. And this one was definitely worth it. In fact I will go as far as saying that it was better than Heroin.
Amobarbital
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Aliases: Blues, Amytal, Blue birds, Blue velvet, Blue devils
Summary
Amobarbital (formerly sold as Amytal and as half of Tuinal) is an intermediate-acting barbiturate that potentiates and directly activates GABA-A receptors. The therapeutic index is narrow: doses above approximately 1.5 g have produced fatal respiratory depression. Because its elimination half-life averages 24 hours, next-day cognitive and motor impairment is common.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50mg | 50-75mg | 75-150mg | 150mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — TripSit
☠ above ≈1.5 g oral
Fatal respiratory depression
“The therapeutic index is narrow: doses above approximately 1.5 g have produced fatal respiratory depression.” — toxicity literature
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 1-4 hrs | 3-5 hrs | 5-9 hrs |
| Intravenous | 1-2 min | 5-10 min | 1-4 hrs | 3-5 hrs | 5-9 hrs |
| Intramuscular | 5-15 min | 15-30 min | 1-4 hrs | 3-5 hrs | 5-9 hrs |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.
No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually. With barbiturates, you get used to the effects much more than to a dangerous dose, so the gap between a dose that works and one that kills shrinks the more you use. Stopping suddenly after regular use can cause convulsions and delirium.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder · Phenobarbital label: drug abuse and dependence
Cross-Tolerances
Other barbiturates
Benzodiazepines
Z-drugs
GABAergic sedatives
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
Amobarbital's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Amobarbital there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "Amobarbital (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
Amobarbital
Unit
mg
Description
Amobarbital Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 50 · common 50-75 · strong 75-150 · heavy 150+ Oral duration: onset 15-30m · come-up 0.5-1h · peak 1-4h · offset 3-5h · total 5-9h · after-effects 2-12h Intravenous duration: onset 1-2m · come-up 5-10m · peak 1-4h · offset 3-5h · total 5-9h · after-effects 2-12h Intramuscular duration: onset 5-15m · come-up 15-30m · peak 1-4h · offset 3-5h · total 5-9h · after-effects 2-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 62.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Amobarbital? Let us know. Reports are reviewed by moderators — this is not posted publicly.