Amitriptyline Limited data

Limited data

Sparse data. Doses and effects may be unreliable or untested.

2 corroborating sources

1 ROA with full dose ladder

PubChem toxicity data

dose data not in PW/TripSit (unverifiable)

dose ladder unverifiable and undisclosed — capped

Aliases: Elavil, Levate

Summary Erowid

Amitriptyline HCl is a tricyclic antidepressant used in the treatment of depression and occasionally sleep disorders.

Dose Information dose.wiki

ROA	Light	Common	Strong	Heavy
Oral	20-50mg	50-100mg	100-150mg	200mg+

Light Common Strong Heavy

Sources

Oral

Dose ladder — dose.wiki

Tolerance

Build-up varies by mechanism; therapeutic tolerance may develop over weeks of regular use

Reset typically days to weeks after discontinuation

Tolerance Decay

Full tolerance 3d Half tolerance 8d Baseline ~14d

Effects Erowid

Aggregated from 25 single-substance Erowid experience reports; 14 Erowid reports where another drug was taken too are left out

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Positive Effects 5

60.0% –

28.0% –

16.0% –

12.0% –

Adverse Effects 4

32.0% –

16.0% –

12.0% –

Also reported in combinations. In the 14 Amitriptyline reports where another drug was taken too, 3 mention hospital, emergency services or an overdose, 1 a seizure and 1 psychosis (too few reports for percentages). In the 25 single-substance reports: 8.0%, 0.0% and 0.0%. These are not in the figures above: they cannot be put down to Amitriptyline alone, and a mention is not always something that happened to the writer.

Combinations

Cross-Check Amitriptyline with another substance

Written here, not TripSit data: TripSit has no tricyclic class. The MAOI entry follows the tricyclic labels, the tramadol entry follows tramadol's US label, and the DXM entry follows the serotonin reasoning behind TripSit's SSRI ratings.

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 8 reports 2 neutral 6 cautionary visit

Snapshots cautionary exp #102292

This report needs to start a few hours before the experience I had. I had woke up at around 12 pm on a Saturday, I was a Senior in high school and it was prom night but I decided not to go because I wasn't about that life. Looking back on it, I should have gone to prom.

Possessed by a Fisher Cat cautionary exp #50303

[Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects. Sometimes extremely high doses reported are errors rather than actual doses used.] Ok.

A Walking Sleep cautionary exp #94157

I've been taking Amitriptyline for three days now as a sort of research method to determine whether or not I should give it the green light for recreational use . After much thought, Amitriptyline is not a fun drug, period. It is indeed for those who need it and have a script for it.

Stoned Without the Mental Confusion neutral exp #34343

I came across a large amount of Amitrityline so I decide to do some research to see what it does and how it could affect me. From the little internet info I was able to get my hands on I managed to find out that it is a Anti-depressive, but is also used for sleeping disorders and as a pain killer.

Weird Mental Disturbances cautionary exp #81154

I decided one night to take Elavil because I had used it twice prior to this, and all it had done was knock me out similarly to the way an antihistamine usually does. I had taken it for the purpose of falling asleep earlier.

Maxed Out neutral exp #55526

My friend has an intestinal disease that causes him a lot of pain so the doctors prescribed him with a lot of painkillers and one was Amitriptyline. My friend called me one night around 2am. Asking me if I wanted to sneak out and meet him.

The Suicide Attempt cautionary exp #44648

This is hard to explain, but here it goes. I've been a long time suffer of depression/anxiety for about 15 years now. Although I've done tones of hallucinogens, up until last year I was only smoking dope and tripping on cactus & M'Gs, hadnt had dope, shrooms or acid for years.

Mood Elevater My Aunt Fannie cautionary exp #32761

I had been suffering migraines for about a month when my mother finally managed to convince me to go to a doctor. He found nothing that he could determine would cause these attacks and sent me to neruolgist.

Bluelight 2 threads 1 neutral 1 cautionary visit

Amitriptyline New Experience A Trip To Planets Unknown cautionary

So this was a couple of years ago but I think it is certainly worthy of a trip report as it was by far one of the craziest 2-3 days of my life. It all started when I was dating a new girl (now the mother of my child and my Fiance).

Amitriptyline First Time 230mg 8 Pillz Blackouts neutral

Alright this is my third trip report and let me start by telling u about my self im 14, 125lbs and about 170cm. The story begins when I told my friend about "new" ways to get high and we could be able to find it in out houses. I started by telling him to look 4 sum T3 because i ahd tried it and knew it worked.

Pill Identifiers

52 known pill identifiers on record — view imprints, colors, shapes, and images

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Amitriptyline's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 Erowid 📖 PsychonautWiki

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track Amitriptyline there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "Amitriptyline (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

Amitriptyline

Unit

Description

Amitriptyline
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10 · light 20-50 · common 50-100 · strong 100-150 · heavy 200+

Oral duration: total 10-28h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 75 mg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Amitriptyline? Let us know. Reports are reviewed by moderators — this is not posted publicly.

Amitriptyline Limited data Limited data Sparse data. Doses and effects may be unreliable or untested. 2 corroborating sources 1 ROA with full dose ladder PubChem toxicity data dose data not in PW/TripSit (unverifiable) dose ladder unverifiable and undisclosed — capped