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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    6-MDDM Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • classified Tentative

    Aliases: 6-methylenedihydrodesoxymorphine

    Depressant Opioid

    Summary TripSit

    Semisynthetic opioid that is a derivative of Hydromorphone with little history of human use. Roughly around ~80x the potency of Morphine. Structurally related to Desomorphine.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong
    Oral 125ug 187-250ug 375ug+
    Light Common Strong
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 1-15 min 4-6 hrs 1-10 hrs 4-6 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 5.4
    Moderate+ 5/10

    Moderate euphoria with mild pain relief and itching/nausea, low sedation

    Euphoria / Warmth ×3
    7
    euphoria cognitive euphoria mood lift
    Analgesia ×2
    4
    analgesia
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    4
    constipation dry mouth
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.

    No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

    Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

    Effects TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check 6-MDDM with another substance

    6-MDDM's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    💊 Pill Identifier 📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 6-MDDM there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    6-MDDM
    Unit
    µg
    Description 
    6-MDDM
Source: SubstanceSearch (substancesearch.com)

Oral dose (µg): light 125ug · common 187-250ug · strong 375ug+

Oral duration: onset 1-15m · peak 4-6h · total 4-6h · after-effects 1-10h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 218.5 µg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.