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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    5F-PB-22 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Research-chemical Cannabinoid

    Summary PsychonautWiki

    5F-PB-22 (1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester also known as 5F-QUPIC) is a synthetic cannabinoid and agonist of the cannabinoid receptors which produces predominantly sedating subjective effects somewhat similar to that of cannabis. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it has been sold as a grey area research chemical through online vendors.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 1-3mg 3-5mg 5-8mg 8mg+
    Smoked 1-3mg 3-5mg 5-8mg 8mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki, TripSit

    Smoked

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 5-10 min 60-90 min 60 min 30-60 min 2-3 hrs
    Smoked <1-2 min 30 min 60 min 15 min 90 min

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 21d Baseline ~28d

    Effects PsychonautWiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check 5F-PB-22 with another substance

    5F-PB-22's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 TripSit 📖 PsychonautWiki
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has 5F-PB-22, but its built-in entry only covers Oral, Smoked. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "5F-PB-22 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Duration (reference) 
    5F-PB-22: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)


Smoked duration: onset <1-2m · peak 30m · offset 1h · total 1.5h · after-effects 15m

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Ranges are harm-reduction guidance, not a prescription.