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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MAPDB Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical

    Aliases: 5mapdb

    Psychedelic Stimulant Empathogen Research-chemical

    Summary dose.wiki TripSit

    5-MAPDB is a dihydrobenzofuran entactogen first characterized by Monte et al. (1993) and pharmacologically profiled by Rickli et al. (2015).

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-75mg 75-120mg 120-150mg 150mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 45-70 min 30-60 min 2-4 hrs 1-2 hrs 2-4 hrs 5-8 hrs
    Insufflated 5-15 min 15-30 min 2-4 hrs 1-2 hrs 2-4 hrs 5-8 hrs
    Rectal 5-15 min 15-30 min 2-4 hrs 1-2 hrs 2-4 hrs 5-8 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.0
    Light 2/10

    Mild auditory effects with mild body load, low visuals

    Visual Intensity ×3
    2
    tracers
    Headspace Depth ×3
    0
    Auditory Effects ×1
    4
    enhanced music appreciation
    ⚠ Body Load / Somatic Effects ×1
    4
    bruxism jaw clenching sweating
    Empathogen 6.3
    Strong 6/10

    Strong sensory enhancement with moderate empathy, mild euphoria, low stimulation

    Empathy / Social Openness ×3
    7
    empathy emotional openness increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    3
    stimulation
    Sensory Enhancement ×1
    10
    enhanced music appreciation enhanced tactile sensation tactile enhancement increased libido
    Stimulant 2.9
    Light+ 3/10

    Mild euphoria with moderate anxiety/jitters, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    6
    bruxism jaw clenching sweating
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects dose.wiki TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • Visual and audiotory hallucinations itchiness

    Combinations TripSit

    Cross-Check 5-MAPDB with another substance

    5-MAPDB's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 5-MAPDB there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "5-MAPDB (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    5-MAPDB
    Unit
    mg
    Description 
    5-MAPDB
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 50-75 · common 75-120 · strong 120-150 · heavy 150+

Oral duration: onset 0.75-1.17h · come-up 0.5-1h · peak 2-4h · offset 1-2h · total 5-8h · after-effects 2-4h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 2-4h · offset 1-2h · total 5-8h · after-effects 2-4h
Rectal duration: onset 5-15m · come-up 15-30m · peak 2-4h · offset 1-2h · total 5-8h · after-effects 2-4h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 97.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.