Not much preparation, just got off a busy busy day of work, last meal eaten was about four hours prior, a flatbread sandwich and some cholesterol free chips, nothing heavy. After an insufflated 5 milligrams for allergy testing, I weighed out 100 milligrams of 5-APDB and parachuted it in some tissue paper.
5-APDB
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- 30 combo interactions documented
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- 30 combo interactions documented
- classified Research-chemical
Summary
An entactogenic amphetamine stimulant with similar structure and effects to MDMA. An analogue of MDA, it is a highly selective serotonin releaser but inhibits reuptake of serotonin (weakly), dopamine and norepinephrine.
Perspectives
“All in all however, this one is a worthy addition to the toolkit. Perhaps its most interesting feature is its total lack of stimulation. Some have gone so far as to describe is as sedating, but I would say its effects on my body were overall neutral. It is psychedelic too, at least mentally.”
Dose Information
| ROA | Light | Common | Heavy |
|---|---|---|---|
| Oral | 50-75mg | 75-125mg | 125-200mg+ |
Light
Common
Heavy
Sources
Oral
Dose ladder — TripSitOnset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 19-60 min | 4-8 hrs | 4-8 hrs |
Effect Profile
1 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
2.8
Light+
3/10
Mild visuals with low body load and headspace
Visual Intensity
×3
4
color enhancement
tracers
Headspace Depth
×3
1
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
3
sweating
increased heart rate
Empathogen
4.1
Moderate
4/10
Moderate sensory enhancement and stimulation with mild euphoria, low empathy
Empathy / Social Openness
×3
2
increased sociability
Euphoria / Mood Elevation
×2
5
euphoria
mood lift
Stimulation
×1
6
stimulation
wakefulness
increased heart rate
Sensory Enhancement
×1
7
tactile enhancement
color enhancement
increased libido
Stimulant
4.0
Moderate
4/10
Mild stimulation and euphoria with moderate anxiety/jitters, low focus
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
5
euphoria
mood lift
Focus / Productivity
×2
2
thought acceleration
Anxiety / Jitters
×1
7
anxiety
increased heart rate
sweating
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
- Visual and audiotory hallucinations itchiness
Combinations
Cross-Check 5-APDB with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 positive visit
Dose.wiki 1 report 1 neutral visit
This is actually only my second time ever taking an empathogen, and my only time taking one alone. This is dangerous stuff. I make a fool of myself every time, I get too lovey dovey, start asking people personal questions and breaching their privacy and…
Bluelight Reference Guide
The Main 5-APDB Thread
5-(2-Aminopropyl)-2,3-dihydrobenzofuran 5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB, 3-Desoxy-MDA, EMA-4) is a putative entactogen drug of the phenethylamine and amphetamine classes.
Read full thread on Bluelight →
5-APDB's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 5-APDB there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
5-APDB
Unit
mg
Description
5-APDB Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 50-75 · common 75-125 · heavy 125-200+ Oral duration: onset 0.32-1h · peak 4-8h · total 4-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 100 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 5-APDB? Let us know. Reports are reviewed by moderators — this is not posted publicly.