4,4-DMAR
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 4,4-dmap, Serotoni, Serotoni, para-methyl-4-methylaminorex
Summary
4,4'-DMAR (para-methyl-4-methylaminorex) is a stimulant of the amphetamine class. It acts as a monoamine releasing agent, with pharmacological properties comparable to MDMA. It is extremely potent, estimated at 5-10 times more potent than MDMA as a monoamine releasing agent, and has a longer duration. Unlike many amphetamines, 4,4'-DMAR lacks TAAR1 agonism, meaning it does not auto-inhibit its own effects, potentially making it more dangerous.
Dose Information
Dose basis. Dose figures for 4,4′-DMAR come from scattered user reports from 2013-2015, not from clinical study. The EU's 2014 risk assessment linked it to 31 deaths in about a year, recorded typical oral doses of 10-60 mg with 10-25 mg described as a low dose, and noted that effects can take more than an hour to start in some people, which leads them to redose. It has also been sold as ecstasy. The ladder follows Drugs.Wiki, which sits at the low end of the EU figures.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-25mg | 25-40mg | 40mg+ |
Sources
Oral
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 2-4 hrs | 2-4 hrs | 4.5-9 hrs |
| Insufflated | 30-60 min | 2-4 hrs | 2-4 hrs | 4.5-9 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Low visuals with moderate body load
Strong stimulation with moderate sensory enhancement, low euphoria and empathy
Strong stimulation and focus with strong anxiety/jitters, mild euphoria
Tolerance
Tolerance Decay
Effects
Effect glossary — · full glossary
Combinations
Cross-Check 4,4-DMAR with another substanceHelpful Links
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The PsychonautWiki Journal logging app doesn't include every substance. To track 4,4-DMAR there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4,4-DMAR Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 1-3 · light 5-10 · common 10-25 · strong 25-40 · heavy 40+ Oral duration: onset 0.5-1h · peak 2-4h · offset 2-4h · total 4.5-9h · after-effects 24h Insufflated duration: onset 0.5-1h · peak 2-4h · offset 2-4h · total 4.5-9h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 17.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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