4-Methylephedrine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 4-me, 4-mmc metabolite, Dihydromephedrone, P-methylephedrine
Summary
4-Methylephedrine (4-ME) is a phase-I reduction metabolite of the popular cathinone mephedrone (4-MMC). In users who take raw or poorly washed 4-MMC, small amounts may already be present as an impurity. Pure 4-ME occasionally appears on the grey market but formal pharmacology is limited.
Dose Information
| ROA | Threshold |
|---|---|
| Oral | 15mg |
| Insufflated | 5-10mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Oral
Dose ladder — DrugsPROInsufflated
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-40 min | 1-2 hrs | 1-3 hrs | 2.33-5.67 hrs |
| Insufflated | 5-10 min | 1-2 hrs | 1-3 hrs | 2.08-5.17 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong stimulation and anxiety/jitters with moderate euphoria
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Effect glossary — · full glossary
Combinations
Cross-Check 4-Methylephedrine with another substanceHelpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Methylephedrine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4-Methylephedrine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 15 Insufflated dose (mg): threshold 5-10 Oral duration: onset 20-40m · peak 1-2h · offset 1-3h · total 2.33-5.67h · after-effects 1-4h Insufflated duration: onset 5-10m · peak 1-2h · offset 1-3h · total 2.08-5.17h · after-effects 1-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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