4-MeO-MiPT 25mg First Trial 2-10-2019 by Xorkoth I recently received a gift of samples of several tryptamines I did not previous have, from a friend who in turn was gifted some other rarities by me. One of them was 4-MeO-MiPT, an unusual substance I had been curious to try for some time.
4-MeO-MiPT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Summary
4-MeO-MiPT (4-methoxy-N-methyl-N-isopropyltryptamine) is a rare synthetic psychedelic first reported by Alexander Shulgin (TiHKAL #39). User reports describe a relatively gentle, tactile, and mood-enhancing experience with mild visual effects and a shorter duration than related tryptamines. Recent pharmacological research reveals 4-MeO-MiPT exhibits potent serotonin reuptake inhibition (SSRI activity, IC50 = 57 nM) alongside 5-HT2A and 5-HT1A receptor agonism, which may account for its atypical psychedelic profile characterized by reduced classical psychedelic effects compared to 4-HO-MiPT and 4-AcO-MiPT.
Perspectives
“This substance isn't particularly exciting or interesting, just a novelty. I had low expectations for it and they were barely even met.”
“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”
Dose Information
| ROA | Light | Common | Strong |
|---|---|---|---|
| Oral | 10mg | 10-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1-2 hrs | 1-2 hrs | 3-7 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 1-2 hrs | 3-7 hrs |
Effect Profile
4 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.8
Moderate
4/10
Strong auditory effects with moderate body load, mild visuals, low headspace
Visual Intensity
×3
5
tracers
drifting
brightened colour
Headspace Depth
×3
1
confusion
Auditory Effects
×1
8
auditory enhancement
auditory distortion
Body Load / Somatic Effects
×1
6
muscle tension
bruxism
jaw tension
sweating
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1d
Half tolerance
7d
Baseline
~10d
Rapid tolerance like other 5‑HT2A psychedelics; spacing sessions by 10–14 days helps restore baseline sensitivity. Evidence level: anecdotal/user‑report across tryptamines; no pharmacokinetic studies for 4‑MeO‑MiPT.
Cross-Tolerances
Other serotonergic psychedelics (e.g., LSD, psilocybin, 4‑HO/4‑AcO tryptamines)
Effects
Aggregated from 4 single-substance Erowid experience reports; 3 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 4 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 4
4 of 4
–
3 of 4
–
3 of 4
–
3 of 4
–
Adverse Effects 0
Combinations
Cross-Check 4-MeO-MiPT with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 6 reports 4 positive 2 neutral visit
(4-MeO-MiPT / ~20mg) - First Time - 'Nice, But Not A Psychedelic' [This is not 4-HO-MiPT or 5-MeO-MiPT, two much more common tryptamines] Background: Experienced with dozens of tryptamine, phenethylamine, and lysergamide psychedelics, as well as quite a few arylcyclohexylamine and other dissociatives, RC stimulants, an...
To make it quick before you have to read the following novella on my lovely afternoon trip, I just wanted to say 2 things: 1. This is my first experience with an illegal drug, even a psychedelic. 2. I am writing this report as the clock ticks, meaning, I'm writing each entry at the time specified.
==Previous tolerance Took a microdose of 8mcg ALD-52 on the previous day, and 5mcg two days prior to that. I don't feel that this affected my tolerance. ==Mindset going into the experience In good spirits, things going well in my personal and professional lives.
Compounds I take daily: Piracetam - 1200 mg Phenibut - 750 mg Vinpocetine - 10 mg Noopept(another racetam) - 15 mg Time from the last recreational substance usage: 1 day, it was 20 mg of 4-AcO-DMT - I didn't like it, but it is the whole different story.
Substance: 50mg 4-MEO-MIPT Expierence: First time Setting: At home, alone Gender: Male Age: 19 The trace effects of diazepam powder remain through my perception for the day and may effect the experience slightly.
Dose.wiki 1 report 1 neutral visit
This substance isn’t particularly exciting or interesting, just a novelty. I had low expectations for it and they were barely even met. The drug primarily manifested as physical discomfort, with all the other effects being subtle and fleeting. I do not think…
PiHKAL / TiHKAL
TiHKAL #39: 4-MeO-MIPT
“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”
4-MeO-MiPT's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4-MeO-MiPT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
4-MeO-MiPT
Unit
mg
Description
4-MeO-MiPT Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 10 · common 10-20 · strong 20+ Oral duration: onset 15-45m · come-up 0.5-1h · peak 1-2h · offset 1-2h · total 3-7h · after-effects 1-3h Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 1-2h · total 3-7h · after-effects 1-3h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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