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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-EPD Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: P-epd, 4-ethylpentedrone, Para-ethyl pentedrone, 4-ethyl-alpha-methylamino-valerophenone

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    4-EPD is a ring-ethyl analogue of pentedrone first detected in European drug-checking samples in 2018. Toxicological information is sparse; a handful of fatal intoxications have been documented, usually with poly-drug use. Acute risks mirror those of other potent cathinones: tachycardia, hypertension, hyperthermia, rhabdomyolysis, hyponatremia from excessive water intake, acute psychosis, and serotonin syndrome when mixed with serotonergics.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 10-20mg 20-30mg 30-50mg 50mg+
    Light Common Strong Heavy
    Sources

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 20-45 min 30-90 min 1-2 hrs 2-8 hrs 1-3 hrs
    Insufflated 5-30 min 30-90 min 1-2 hrs 2-8 hrs 1-3 hrs
    Rectal 5-15 min 30-90 min 1-2 hrs 2-8 hrs 1-3 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.1
    Moderate 4/10

    Moderate euphoria with strong anxiety/jitters, mild focus, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • Anxiolysis or Anxiety
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check 4-EPD with another substance

    4-EPD's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-EPD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-EPD (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-EPD
    Unit
    mg
    Description 
    4-EPD
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): light 10-20 · common 20-30 · strong 30-50 · heavy 50+

Oral duration: onset 20-45m · peak 0.5-1.5h · offset 1-2h · total 1-3h · after-effects 2-8h
Insufflated duration: onset 5-30m · peak 0.5-1.5h · offset 1-2h · total 1-3h · after-effects 2-8h
Rectal duration: onset 5-15m · peak 0.5-1.5h · offset 1-2h · total 1-3h · after-effects 2-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 25 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.