Preface: The next 3 paragraphs are heavy pharm/chem jargon, skip to the bottom of the preface for a summary of this new dissociative, skip to the end of the preface for my full report. 3,4-MD-PCP is yet another new arylcyclohexylamine.
3,4-MD-PCP
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Mdpcp
Summary
NMDA receptor affinity approximately 62 nM, placing potency between 3-MeO-PCP and ketamine. Users describe warm, chameleonic dissociation that varies dramatically with dose and setting, ranging from lucid sociability at low doses to overwhelming mania at high doses. The dose-response curve is steep above 40 mg.
Perspectives
“As far as commonalities go, I would say it is smooth, insightful, a bit manic, colorful, warm, euphoric, and sociable. It is a dizzy and functional dissociative, towing a line between being great for getting up and doing stuff while also being great for just lying in the dark.”
Dose Information
| ROA | Light | Common |
|---|---|---|
| Oral | 5-20mg | 20-40mg |
Light
Common
Sources
Oral
Dose ladder — dose.wikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 2-4 hrs | 3-5 hrs | 5.75-10.75 hrs |
| Insufflated | 4-15 min | 15-30 min | 2-4 hrs | 3-5 hrs | 5.32-9.75 hrs |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.6
Strong+
7/10
Strong dissociative depth and motor impairment with mild insight and mania
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
spatial disorientation
+2 more
Mania / Compulsion
×1
4
disinhibition
stimulation
Insight / Novel Thought
×2
5
conceptual thinking
analysis enhancement
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check 3,4-MD-PCP with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 positive visit
Bluelight Reference Guide
Dissociatives The Small & Handy 3,4-MD-PCP thread
Once again just copying what I shared to reddit The lab that sent me the sample of this hasn't officially announced this one yet but I'm 99% sure I have permission to share and I was too excited about this to wait.
Read full thread on Bluelight →
3,4-MD-PCP's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 3,4-MD-PCP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
3,4-MD-PCP
Unit
mg
Description
3,4-MD-PCP Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 5 · light 5-20 · common 20-40 Insufflated dose (mg): threshold 2-3 Oral duration: onset 15-45m · come-up 0.5-1h · peak 2-4h · offset 3-5h · total 5.75-10.75h · after-effects 2-8h Insufflated duration: onset 4-15m · come-up 15-30m · peak 2-4h · offset 3-5h · total 5.32-9.75h · after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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