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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3,4-CFPP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 3,4-cfp, 3cl-4f-p, Kleferein, 3-chloro-4-fluoro-piperein

    Summary dose.wiki

    Very little pharmacological or toxicological data exists. Based on structural similarity to mCPP and TFMPP, this compound likely acts as a non-selective serotonin receptor agonist and serotonin releaser. These phenylpiperazines are notorious for producing nausea, migraines, anxiety, and dysphoria rather than euphoria.

    Dose Information Drugs.Wiki

    Dose basis. Oral: Ranges are compiled from scattered user reports and by analogy to related phenylpiperazines; no formal human data exist. Always allergy test (โ‰ˆ1โ€“2 mg) and use a calibrated milligram scale. Expect more nausea and headache than with classical empathogens; redosing tends to increase adverse effects disproportionately. Evidence quality: anecdotal. Insufflated: Phenylpiperazines can be irritating to mucosa and more likely to cause headaches and nausea when snorted; TFMPP/pFPP reports specifically note sore throat/nasal irritation. Prefer oral route for lower adverse-event rates. Evidence: user reports on piperazines; no CFPP-specific data. Evidence quality: anecdotal. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 20-50mg 50-100mg 100-150mg 150mg+
    Insufflated 5-15mg 15-40mg 40-70mg 70mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1-3 hrs 1-2 hrs 1-6 hrs 2.33-6 hrs
    Insufflated 5-15 min 1-3 hrs 1-2 hrs 1-6 hrs 2.08-5.25 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 4.0
    Moderate 4/10

    Moderate stimulation with mild euphoria, low empathy and sensory enhancement

    Empathy / Social Openness ×3
    3
    empathy enhancement
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    6
    physical stimulation restlessness teeth grinding
    Sensory Enhancement ×1
    3
    color enhancement
    Stimulant 3.4
    Light+ 3/10

    Mild stimulation and euphoria with strong anxiety/jitters

    Stimulation / Energy ×3
    5
    physical stimulation alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    8
    anxiety restlessness teeth grinding

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3โ€“7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects dose.wiki

    Positive
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 3,4-CFPP with another substance

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    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3,4-CFPP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3,4-CFPP (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3,4-CFPP
    Unit
    mg
    Description
    3,4-CFPP
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): threshold 20 ยท light 20-50 ยท common 50-100 ยท strong 100-150 ยท heavy 150+
    Insufflated dose (mg): threshold 5 ยท light 5-15 ยท common 15-40 ยท strong 40-70 ยท heavy 70+
    
    Oral duration: onset 0.33-1h ยท peak 1-3h ยท offset 1-2h ยท total 2.33-6h ยท after-effects 1-6h
    Insufflated duration: onset 5-15m ยท peak 1-3h ยท offset 1-2h ยท total 2.08-5.25h ยท after-effects 1-6h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 75 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.