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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-MeO-PCPr Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: 3-methoxyphencyclidine propylamino

    Dissociative Stimulant Research-chemical

    Summary dose.wiki TripSit

    3-MeO-PCPr is a potent N-propyl analogue of 3-MeO-PCP with high NMDA receptor affinity (Ki = 25 nM). It is notably more stimulating and euphoric than many related dissociatives due to pronounced dopamine reuptake inhibition, which significantly increases compulsive redosing risk. Individual sensitivity varies widely.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-8mg 8-15mg 15-20mg 20mg+
    Insufflated 1-3mg 3-8mg 8-15mg 15mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-30 min 30-60 min 2-4 hrs 2-4 hrs 1-12 hrs 4.75-9.5 hrs
    Insufflated 5-10 min 15-30 min 1-3 hrs 2-3 hrs 1-8 hrs 3.33-6.67 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 3.4
    Light+ 3/10

    Strong dissociative depth with strong mania and motor impairment

    Dissociative Depth ×3
    8
    depersonalization physical disconnection visual disconnection spatial disorientation amnesia
    ⚠ Mania / Compulsion ×1
    10
    mania compulsive redosing disinhibition stimulation
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Stimulant 3.6
    Moderate 4/10

    Moderate euphoria with low stimulation and anxiety/jitters

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Estimates reflect community experience with arylcyclohexylamines (rapid tolerance build with partial reversal over 1–4 weeks) and should be treated as approximate. Cross‑tolerance across NMDA antagonists is expected but extent varies.

    Cross-Tolerances

    3-MeO-PCP
    MXE / DMXE
    Ketamine / DCK

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 3-MeO-PCPr with another substance

    3-MeO-PCPr's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3-MeO-PCPr there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3-MeO-PCPr (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3-MeO-PCPr
    Unit
    mg
    Description 
    3-MeO-PCPr
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 5-8 · common 8-15 · strong 15-20 · heavy 20+
Insufflated dose (mg): light 1-3 · common 3-8 · strong 8-15 · heavy 15+

Oral duration: onset 15-30m · come-up 0.5-1h · peak 2-4h · offset 2-4h · total 4.75-9.5h · after-effects 1-12h
Insufflated duration: onset 5-10m · come-up 15-30m · peak 1-3h · offset 2-3h · total 3.33-6.67h · after-effects 1-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 11.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.