3-MeO-PCE Stats & Data

3-MeO-PCE emerged on the online research chemical market around 2010, where it was marketed as a grey-area legal alternative to controlled dissociatives such as PCP and ketamine. The compound represents part of the broader wave of designer arylcyclohexylamines that became available through online vendors during this period. Very little formal research exists regarding this substance, and it has a notably brief history of documented human usage. Its emergence drew regulatory attention alongside related compounds, with the UK's Advisory Council on the Misuse of Drugs specifically mentioning 3-MeO-PCE in their October 2012 report on methoxetamine, which recommended control of analogous arylcyclohexylamines.

The toxicity and long-term health effects of recreational 3-MeO-PCE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 3-MeO-PCE has very little history of human usage.

Effects aggregated from 11 experience reports (11 single-substance Erowid)

Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

Too few reports for bars: these effects come from 11 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Also reported in combinations. In the 13 3-MeO-PCE reports where another drug was taken too, 3 mention hospital, emergency services or an overdose, 1 a seizure and 4 psychosis (too few reports for percentages). In the 11 single-substance reports: 0, 0 and 3. These are not in the figures above: they cannot be put down to 3-MeO-PCE alone, and a mention is not always something that happened to the writer.

From 75 of 78 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

Most co-occurring substances, as a share of all 24 reports filed under 3-MeO-PCE; whiskers are 95% intervals

Most common forms and preparations, as a share of the 20 reports that give one; whiskers are 95% intervals

Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.

Redosing behavior across 21 reports