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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-MEC Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: 3-meec

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    3-Methylethcathinone (3-MEC, 3-MeEC) is the 3-methyl positional isomer of 4-MEC and a close analogue of mephedrone. It emerged on the grey market around 2010-2012 and is usually encountered as an off-white crystalline powder. Pharmacological data are extremely sparse; limited in vitro assays suggest it acts primarily as a dopamine/norepinephrine releaser and reuptake inhibitor with weaker serotonergic activity than 4-MMC or MDMA.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-175mg 175-250mg 250mg+
    Insufflated 25-50mg 50-100mg 100-150mg 150mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-90 min 45-90 min 1-2 hrs 30-60 min 2-5 hrs 2.75-6 hrs
    Insufflated 5-10 min 10-15 min 20-40 min 30-60 min 1-3 hrs 1.08-2.09 hrs
    Rectal 10-20 min 15-30 min 45-90 min 30-60 min 2-4 hrs 1.67-3.33 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 3.6
    Moderate 4/10

    Moderate sensory enhancement and stimulation with low euphoria and empathy

    Empathy / Social Openness ×3
    2
    enhanced sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    6
    physical stimulation wakefulness increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 3.9
    Moderate 4/10

    Mild stimulation and focus with strong anxiety/jitters, low euphoria

    Stimulation / Energy ×3
    5
    physical stimulation wakefulness
    Euphoria / Mood Lift ×2
    3
    euphoria
    Focus / Productivity ×2
    5
    focus enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety jitteriness bruxism increased heart rate jaw tension vasoconstriction +1 more
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative

    Combinations

    Cross-Check 3-MEC with another substance

    3-MEC's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3-MEC there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3-MEC (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3-MEC
    Unit
    mg
    Description 
    3-MEC
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 50-100 · common 100-175 · strong 175-250 · heavy 250+
Insufflated dose (mg): light 25-50 · common 50-100 · strong 100-150 · heavy 150+

Oral duration: onset 0.5-1.5h · come-up 0.75-1.5h · peak 1-2h · offset 0.5-1h · total 2.75-6h · after-effects 2-5h
Insufflated duration: onset 5-10m · come-up 10-15m · peak 20-40m · offset 0.5-1h · total 1.08-2.09h · after-effects 1-3h
Rectal duration: onset 10-20m · come-up 15-30m · peak 0.75-1.5h · offset 0.5-1h · total 1.67-3.33h · after-effects 2-4h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 137.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.