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    Disclaimer
    ⚠ PCP and its analogues are potent dissociatives with significant risk of psychosis, violent behavior, and overdose. Effects are highly unpredictable and dose-sensitive.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-EtO-PCP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Dissociative Research-chemical

    Summary dose.wiki

    3-EtO-PCP is a novel arylcyclohexylamine with an ethoxy substituent at the 3-position of the phenyl ring, making it a heavier and more lipophilic analogue of 3-MeO-PCP. User reports suggest strong dissociation with a sedating, muddy headspace more similar to DCK than the manic clarity of 3-MeO-PCP. Insufflation causes severe nasal pain and prolonged throat irritation; oral or sublingual administration is recommended.

    Dose Information Drugs.Wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    Dose basis. Community-derived; start low and titrate. Avoid redosing for at least 2 hours due to delayed cresting of effects. Use a calibrated milligram scale or volumetric dosing to prevent large missteps. Multiple user reports describe intense delayed nasal/throat burn and lingering soreness; oral administration is generally safer on mucosa. Consider avoiding this ROA. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 30-50mg 50-80mg 80-120mg 120mg+
    Insufflated 10-25mg 25-50mg 50-80mg 80mg+
    Vaporized / Smoked 5-15mg 15-30mg 30-50mg 50mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Vaporized / Smoked

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-45 min 1-3 hrs 2-4 hrs 4-8 hrs 3.5-7.75 hrs
    Insufflated 10-20 min 1-3 hrs 2-4 hrs 4-8 hrs 3.17-7.33 hrs
    Vaporized / Smoked 1-5 min 1-2 hrs 2-3 hrs 4-8 hrs 3.02-5.08 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.0
    Strong 6/10

    Strong dissociative depth and motor impairment with mild mania, low insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection spatial disorientation memory suppression +1 more
    ⚠ Mania / Compulsion ×1
    4
    disinhibition stimulation
    Insight / Novel Thought ×2
    3
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Half tolerance 14d Baseline ~28d

    Community consensus: rapid functional tolerance after one heavy session; partial fade in several days; baseline often in 10–14 days. Cross‑tolerance likely with other arylcyclohexylamines (e.g., PCP, ketamine, 3‑MeO‑PCP) and possibly DXM.

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 3-EtO-PCP with another substance

    3-EtO-PCP's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3-EtO-PCP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3-EtO-PCP (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3-EtO-PCP
    Unit
    mg
    Description 
    3-EtO-PCP
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 20-30 · light 30-50 · common 50-80 · strong 80-120 · heavy 120+
Insufflated dose (mg): threshold 10 · light 10-25 · common 25-50 · strong 50-80 · heavy 80+
Vaporized / Smoked dose (mg): threshold 5 · light 5-15 · common 15-30 · strong 30-50 · heavy 50+

Oral duration: onset 30-45m · peak 1-3h · offset 2-4h · total 3.5-7.75h · after-effects 4-8h
Insufflated duration: onset 10-20m · peak 1-3h · offset 2-4h · total 3.17-7.33h · after-effects 4-8h
Vaporized / Smoked duration: onset 1-5m · peak 1-2h · offset 2-3h · total 3.02-5.08h · after-effects 4-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 65 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.