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    Disclaimer
    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    ☢ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25T-2-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: N-bomb, 2c-t-2-nbome, 25t2-nbome

    Psychedelic Research-chemical

    Summary dose.wiki TripSit

    25T-2-NBOMe is a highly potent NBOMe derivative active in the microgram range. This compound is the N-(2-methoxybenzyl) derivative of 2C-T-2 and exhibits significantly increased potency compared to its parent compound. Accurate measurement with a 0.001 g (milligram) scale or volumetric dosing is essential; visual dosing is extremely dangerous and responsible for most NBOMe hospitalisations and fatalities.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Sublingual 100-300ug 300-600ug 600-1000ug 1000ug+
    Buccal 100-300ug 300-600ug 600-1000ug 1000µg+
    Light Common Strong Heavy
    Sources

    Sublingual

    Dose ladder — dose.wiki, TripSit

    Buccal

    Dose ladder — Light–Heavy: same as the Sublingual row (dose.wiki, TripSit); no source states these Buccal figures

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 15-45 min 30-60 min 1-3 hrs 3-6 hrs 2-10 hrs 6-10 hrs
    Buccal 15-45 min 30-60 min 1-3 hrs 3-6 hrs 2-10 hrs 6-10 hrs
    Insufflated 5-15 min 15-30 min 1-3 hrs 3-6 hrs 2-10 hrs 6-10 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.4
    Strong 6/10

    Strong visuals with strong body load, moderate auditory effects, mild headspace

    Visual Intensity ×3
    10
    visual geometry colour enhancement synesthesia drifting tracers visual enhancement +1 more
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    7
    auditory distortion synesthesia
    ⚠ Body Load / Somatic Effects ×1
    8
    vasoconstriction nausea temperature regulation suppression increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Cross-tolerance likely with other 5-HT2A psychedelics. Rapid acute tolerance after one session; partial tolerance may persist for about a week. Values are approximate and based on community/series reports rather than controlled studies.

    Cross-Tolerances

    LSD
    Psilocybin
    2C-x phenethylamines
    Other NBOMes

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Neutral

    Combinations TripSit

    Cross-Check 25T-2-NBOMe with another substance

    25T-2-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25T-2-NBOMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "25T-2-NBOMe (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    25T-2-NBOMe
    Unit
    µg
    Description 
    25T-2-NBOMe
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): light 100-300ug · common 300-600ug · strong 600-1000ug · heavy 1000ug+
Buccal dose (µg): threshold 50ug · light 100-300ug · common 300-600ug · strong 600-1000ug · heavy 1000+

Sublingual duration: onset 15-45m · come-up 0.5-1h · peak 1-3h · offset 3-6h · total 6-10h · after-effects 2-10h
Buccal duration: onset 15-45m · come-up 0.5-1h · peak 1-3h · offset 3-6h · total 6-10h · after-effects 2-10h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-3h · offset 3-6h · total 6-10h · after-effects 2-10h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 450 µg (Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.