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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25I-NBMD Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 28 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Cimbi-29, Nbmd-2c-i

    Psychedelic Research-chemical

    Summary dose.wiki TripSit

    25I-NBMD is a highly potent benzylated phenethylamine with a 2,3-methylenedioxy group on the N-benzyl moiety, differing structurally from NBOMe analogues. Sub-milligram accuracy is essential; use a 0.001 mg analytical balance and volumetric dosing. Vasoconstriction, tachycardia, and peripheral numbness are commonly reported.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Sublingual 800-1500ug 1500-2000ug 2000-3000ug 3000ug+
    Light Common Strong Heavy
    Sources

    Sublingual

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 15-40 min 30-60 min 1-3 hrs 2-4 hrs 1-8 hrs 4-6 hrs
    Insufflated 5-20 min 20-40 min 1-3 hrs 2-4 hrs 1-8 hrs 4-6 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.6
    Strong+ 7/10

    Strong visuals with moderate auditory effects and body load, mild headspace

    Visual Intensity ×3
    10
    color enhancement synesthesia drifting tracers color shifting pattern recognition enhancement
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    7
    auditory distortion synesthesia
    ⚠ Body Load / Somatic Effects ×1
    6
    vasoconstriction nausea increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~10d

    Rapid cross-tolerance with other 5‑HT2A psychedelics is expected; conservative spacing of ≥10–14 days between experiences helps restore baseline sensitivity. Data are anecdotal due to limited human studies.

    Cross-Tolerances

    LSD
    Psilocybin

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Neutral

    Combinations TripSit

    Cross-Check 25I-NBMD with another substance

    25I-NBMD's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25I-NBMD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "25I-NBMD (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    25I-NBMD
    Unit
    µg
    Description 
    25I-NBMD
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): light 800-1500ug · common 1500-2000ug · strong 2000-3000ug · heavy 3000ug+

Sublingual duration: onset 15-40m · come-up 0.5-1h · peak 1-3h · offset 2-4h · total 4-6h · after-effects 1-8h
Insufflated duration: onset 5-20m · come-up 20-40m · peak 1-3h · offset 2-4h · total 4-6h · after-effects 1-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1750 µg (Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.