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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25C-NB3OMe Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • descriptive-only dose data
    • duration data present
    • 28 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 30c-nbome, 2c-c-nb3ome, Nb3ome-2c-c, 25c-nb345ome

    Psychedelic Research-chemical

    Summary dose.wiki

    C30-NBOMe (also known as 30C-NBOMe or 25C-NB345OMe) is structurally distinct from typical NBOMes due to its 3,4,5-trimethoxybenzyl group (mescaline-like pattern) rather than the standard 2-methoxybenzyl group. Despite being theoretically related to active NBOMe compounds, extensive anecdotal evidence from 2013-2016 indicates this substance produces minimal to no psychoactive effects at doses ranging from micrograms to hundreds of milligrams across multiple routes of administration. Only one isolated positive report exists amid numerous reports of complete inactivity.

    Dose Information source not identified

    ROA Heavy
    Oral No reliable effects at 300+ mg
    Sublingual No effects observed at 50+ mg
    Intravenous No effects reported at 20 mg
    Heavy
    Sources· no ladder identified

    Oral

    Dose ladder — source not identified

    Sublingual

    Dose ladder — source not identified

    Intravenous

    Dose ladder — source not identified

    Onset, Duration & After-effects dose.wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Buccal 20-60 min 30-60 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs 4.33-9.5 hrs
    Insufflated 5-20 min 15-30 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs 3.83-8.33 hrs
    Oral 30-90 min 45-90 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs 4.75-10.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.0
    Strong 6/10

    Strong visuals, body load, and auditory effects with mild headspace

    Visual Intensity ×3
    9
    visual geometry color enhancement drifting tracers visual distortions
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    8
    auditory enhancement auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    9
    body load nausea teeth grinding increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Patterns extrapolated from classical psychedelic tolerance; individual variability is high. Repeated high‑frequency use may cause prolonged after‑effects or HPPD‑like symptoms as reported anecdotally.

    Cross-Tolerances

    LSD
    2C-series phenethylamines
    other NBOMe/NBOH psychedelics

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • No consistent psychoactive effects reported
    Positive
    Neutral

    Combinations

    Cross-Check 25C-NB3OMe with another substance

    25C-NB3OMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25C-NB3OMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    25C-NB3OMe
    Unit
    mg
    Description 
    25C-NB3OMe
Source: SubstanceSearch (substancesearch.com)

Buccal dose: threshold 200-400
Insufflated dose: threshold 100-300
Oral dose: threshold No effects reported at standard doses · heavy No reliable effects at 300+ mg
Sublingual dose: threshold Unknown - no reliable effects reported · heavy No effects observed at 50+ mg
Intravenous dose: threshold — · heavy No effects reported at 20 mg

Buccal duration: onset 0.33-1h · come-up 0.5-1h · peak 1.5-3.5h · offset 2-4h · total 4.33-9.5h · after-effects 2-6h
Insufflated duration: onset 5-20m · come-up 15-30m · peak 1.5-3.5h · offset 2-4h · total 3.83-8.33h · after-effects 2-6h
Oral duration: onset 0.5-1.5h · come-up 0.75-1.5h · peak 1.5-3.5h · offset 2-4h · total 4.75-10.5h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.