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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-PTA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • classified Tentative
    • classified Research-chemical

    Aliases: Cumylamine, 4-methyl-2-pa, 2-(p-tolyl)acetamide

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    Human data remain extremely limited (≀50 self-reports). Acute adverse effects recorded include marked tachycardia (>130 bpm), vasoconstriction, jaw tension, blurred vision and short-lived chest discomfort at β‰₯60 mg. Because the amide replaces the Ξ±-methyl, potency is roughly one-quarter of amphetamine but pressor effects are still pronounced.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Oral 10-20mg 20-40mg 40-80mg 80+mg
    Sublingual 10-20mg 20-40mg 40-80mg 80+mg
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Sublingual

    Dose ladder — Light–Heavy: same as the Oral row (dose.wiki, TripSit); no source states a Sublingual ladder

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 10-25 min 45-90 min 30-60 min 1-6 hrs 1-3 hrs
    Insufflated 2-8 min 45-90 min 30-60 min 1-6 hrs 1-3 hrs
    Sublingual 10-25 min 45-90 min 30-60 min 1-6 hrs 1-3 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.9
    Moderate+ 5/10

    Strong focus with strong anxiety/jitters, mild euphoria, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    10
    focus enhancement enhanced focus cognitive enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety tachycardia teeth grinding increased heart rate vasoconstriction
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    2-PTA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    πŸ“– dose.wiki πŸ“– TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-PTA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-PTA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-PTA
    Unit
    mg
    Description 
    2-PTA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 10-20 Β· common 20-40 Β· strong 40-80 Β· heavy 80+
Sublingual dose (mg): threshold 5 Β· light 10-20 Β· common 20-40 Β· strong 40-80 Β· heavy 80+

Oral duration: onset 10-25m Β· peak 0.75-1.5h Β· offset 0.5-1h Β· total 1-3h Β· after-effects 1-6h
Insufflated duration: onset 2-8m Β· peak 0.75-1.5h Β· offset 0.5-1h Β· total 1-3h Β· after-effects 1-6h
Sublingual duration: onset 10-25m Β· peak 0.75-1.5h Β· offset 0.5-1h Β· total 1-3h Β· after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.