This is another one theorized to be a prodrug to LSD, as are most lysergamides it seems. Yet this one seems to have stood out in several ways- Firstly, the visuals- most lysergamides carry a distinct class of visual for me, reminiscent of art produced by…
1B-LSD
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: 1b, 1-butyryl-lsd
Summary
1B-LSD is an N1-acylated prodrug that is rapidly hydrolyzed in vitro and in vivo to LSD via CYP1A2 and CYP3A4 enzymes. Animal studies show approximately 14% the potency of LSD by weight; blotters marketed at 100 ug 1B-LSD produce subjective effects comparable to 75-100 ug LSD in many users. Because it is a prodrug, CYP1A2/3A4 inhibitors or inducers could alter intensity and onset.
Perspectives
“The overall attributes of the trip I would describe as lucidity, with light overall visuals mostly built of alterations, but with an underlying cognitive intensity and depth that makes for a truly profound, though not necessarily intense, experience.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 15-50µg | 50-125µg | 125-250µg | 250µg+ |
| Sublingual | 25-75µg | 75-150µg | 150-300µg | 300µg+ |
Light
Common
Strong
Heavy
Sources· 1 of 2 ladders not identified
Oral
Dose ladder — dose.wikiSublingual
Dose ladder — source not identifiedOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-60 min | 0.75-2 hrs | 3-5 hrs | 3-5 hrs | 8-12 hrs |
| Sublingual | 19-60 min | 0.75-2 hrs | 3-5 hrs | 3-5 hrs | 8-12 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
9.2
Intense+
9/10
Strong visuals, headspace, and auditory effects with moderate body load
Visual Intensity
×3
10
colour enhancement
tracers
synaesthesia
drifting
pattern recognition enhancement
scenery slicing
+4 more
Headspace Depth
×3
10
conceptual thinking
personal meaning enhancement
recursion
multiple thought streams
emotion enhancement
personality regression
+2 more
Auditory Effects
×1
10
auditory distortion
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
6
nausea
vasoconstriction
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1d
Half tolerance
5d
Baseline
~14d
Rapid tolerance after a single session; meaningful reduction after ~5–7 days; near‑baseline by ~14 days is typical for LSD‑like psychedelics. Data are based on human experience and general psychedelic pharmacology rather than controlled trials.
Cross-Tolerances
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check 1B-LSD with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Dose.wiki 1 report 1 positive visit
Bluelight Reference Guide
Lysergamides The Small & Handy 1-Bu-LSD (1B-LSD) Thread
Apparently vendors are sending out samples for testing right now. Its supposed to be similar to ALD-52 and 1P-LSD. The exact chemical structure isnt out yet but it should be pretty easy to guess. Is it even active ? I have a feeling its not but Id love for someone with more knowledge to correct me
Read full thread on Bluelight →
1B-LSD's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has 1B-LSD, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "1B-LSD (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Custom Unit doses
- Sublingualcommon ~ 112.5 µg
Dose & duration (reference)
1B-LSD: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Sublingual dose (µg): threshold 15-25ug · light 25-75 · common 75-150 · strong 150-300 · heavy 300+ Sublingual duration: onset 0.32-1h · come-up 0.75-2h · peak 3-5h · offset 3-5h · total 8-12h · after-effects 6-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
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