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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    1,4-Butanediol Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 5 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Aliases: Bd, Bdo, 4-b, 1,4-b, 1,4-bd, 14bd

    Summary dose.wiki Erowid TripSit PsychonautWiki

    1,4-BDO is a prodrug for GHB, metabolized by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Individual metabolic variability means two users can respond very differently to the same dose. Onset is slower than GBL, making redosing particularly risky as people often mistakenly believe the first dose was weak.

    Dose Information Drugs.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 0.5-1mL 1-2.5mL 2.5-4mL 4mL+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki, PsychonautWiki
    ⚠ above 4 mL oral Unrousable sleep

    “Swiss harm-reduction guidance lists BDO oral low/common/high bands of roughly 0.5-1.0 mL, 1.0-2.5 mL, and 2.5-4.0 mL, with >4 mL commonly producing unrousable sleep; they explicitly advise not to redose for at least 2 hours because delayed stacking is a frequent cause of overdose.” — Swiss harm-reduction guidance via dose.wiki

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 7-30 min 30-60 min 30-90 min 2-4 hrs 1-2 hrs 4-5 hrs

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually. With GHB and GBL, tolerance drops after you stop, so the amount you used to take can cause an overdose, and the gap between the dose you want and an overdose is small and hard to judge.

    Sources: FRANK: benzodiazepines Β· Alcohol and Drug Foundation: GHB Β· FDA 2020: benzodiazepine boxed warning Β· FDA 2019: gabapentinoids and breathing Β· NHS: alcohol use disorder Β· FRANK: GHB

    Effects Erowid

    Aggregated from 44 single-substance Erowid experience reports; 15 Erowid reports where another drug was taken too are left out

    Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

    Positive Effects 6

    22.7% (95% interval 13 to 37 percent) –
    22.7% (95% interval 13 to 37 percent) –
    13.6% (95% interval 6 to 27 percent) –
    11.4% (95% interval 5 to 24 percent) –
    9.1% (95% interval 4 to 21 percent) –
    6.8% (95% interval 2 to 18 percent) –

    Adverse Effects 7

    22.7% (95% interval 13 to 37 percent) –
    22.7% (95% interval 13 to 37 percent) –
    22.7% (95% interval 13 to 37 percent) –
    13.6% (95% interval 6 to 27 percent) –
    9.1% (95% interval 4 to 21 percent) –
    9.1% (95% interval 4 to 21 percent) –
    6.8% (95% interval 2 to 18 percent) –

    Also reported in combinations. In the 15 1,4-Butanediol reports where another drug was taken too, 5 mention hospital, emergency services or an overdose, 2 a seizure and 0 psychosis (too few reports for percentages). In the 44 single-substance reports: 34.1%, 9.1% and 0.0%. These are not in the figures above: they cannot be put down to 1,4-Butanediol alone, and a mention is not always something that happened to the writer.

    Combinations

    Cross-Check 1,4-Butanediol with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 8 reports 2 neutral 6 cautionary visit
    A Unique Hard Drug cautionary exp #117203

    1,4 Β– Butanediol (0.2ml, 0.5ml, 0.7ml, 1.0ml, 1.2ml, 1.5ml, 1.7ml, 2.0ml, 2.5ml, 3.0ml, 3.5ml) Text: The birds who drop drugs into my window gave me a free 50ml sample of 1,4 Β– Butanediol. I felt pretty good about trying it. The first time IΒ’d read about this niche drug was more than 20 years ago.

    Fleming · 0.2 - 3.5 ml oral
    Not a Good Idea cautionary exp #85107

    I donΒ’t normally feel inclined to write on forums, I read them, make a judgment and act. Heck, often I already know what I want to do, but I read the articles for that one out of thousands that conforms to what I want to do and itΒ’s settled.

    G-head · repeated oral
    Hippy Gin and Juice neutral exp #5521

    After much trial and error, usually accompanied by an overwhelming sensation of riding a psychedelic tilt-a-whirl, like being too drunk, but a bit more lucid (so you can think about how stupid it was to drink a second helping), I have arrived at 5ml of 1,4B stirred into an 8 oz. glass of citrus juice as the right mix.

    Catfish Rivers · oral
    Not Sleepy, But Fun neutral exp #6747

    I heard about 1,4 while searching for a non prescription sleep aid that did not interfere with the natural stages of sleep. Indirectly I found out that 1,4 was used recreationally and a larger percentage of it activates the natural production of GHB in the body.

    JJarnigon · 2.5 ml oral / 2.0 ml oral / 2.0 ml oral / 2.0 ml oral
    Toxicity After Infrequent Use cautionary exp #14352

    I wrote this over a year ago and find it as pertinent as ever: Β“IΒ’ve recently posted on various message boards about 1,4 Butanediol and have come to a disappointing conclusion.

    Meat Nipples · 7.5 ml oral
    Terrible Anxiety and Depression Till This Day cautionary exp #116617

    1,4-BDO Is Highly Addictive and Can Be Deadly I'm gonna try and keep this short and to the point. I'm writing this because lately there's so many ppl/kids using all of these research chems etc, and I'd like to try and save as many ppl/especially kids from trying this BDO and having it ruin and/or permanently damage the...

    BDO USER · repeated oral
    On Life Support in the Hospital cautionary exp #7315

    After having heard a little on the radio about the new 'legal' form of GHB floating around the market in Australia I did a little research and was surprised at how easy it was to obtain two litres of 1,4 Butanediol for a very reasonable price.

    Fishboy · 3.0 ml oral / 3.0 ml oral / 3.0 ml oral
    1,4-B Is Not a Toy cautionary exp #10082

    im telling this story to provide anyone who wants to try 1,4b.it is a highly addictive substance not a toy. i started useing this substance over a 1 1/2 yrs ago. i tried it and loved it no nasty beer breath but with all the effects. so i bought a bunch of it. none for sale all for myself.

    Anonymous · repeated oral
    Bluelight 2 threads 1 neutral 1 cautionary visit
    1 4 Bdo New Experience One Hell Of A Bad Experience cautionary

    This is a collection of experiences and overall reflection of the chemical 1,4 BDO. For those who don't want to read through my background info and collection of 1,4 BDO experiences, you can start with the 8th paragraph which is the primary focus of this report.

    1 4 Butanediol And Insomnia neutral

    Fuck that shit! I'd recommend staying away from it. I've been experiencing difficulties with going to sleep and especially sleeping through the whole night for my whole life. So I bought a bottle, took 4.5ml first day - felt good. Slept good. That's what I bought it for.

    →

    Helpful Links

    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes 1,4-Butanediol, but its built-in data can be thinner than ours. Importing this file adds a separate "1,4-Butanediol (Substance Search)" custom substance with our dose ranges and durations, so you can log against whichever you prefer. It leaves tolerance out on purpose, for the reason given under Tolerance above.

    ⬇ Download import file Import this file as custom substances and you get "1,4-Butanediol (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.