Chemical Class
Botanical preparation
Psychoactive Class
Psychedelic
Receptor Profile
Receptor Actions
Agonists
5-HT2A receptor agonist (partial)
5-HT1A receptor agonist
Inhibitors
Serotonin reuptake inhibitor (weak)
Norepinephrine reuptake inhibitor (weak)
Dopamine reuptake inhibitor (weak)
Toxicity
PsychonautWikiWhile yopo is often mixed with calcium hydroxide to improve nasal absorption, this caustic substance can irreversibly damage skin upon contact. Use responsibly.
Effect Profile
Curated + 2 Reports
Psychedelic
3.5
Moderate visuals with strong body load, low headspace
Visual Intensity×3
6
Headspace Depth×3
3
Auditory Effects×1
0
Body Load / Somatic Effects×1
9
Empathogen
4.6
Moderate stimulation, sensory enhancement, and euphoria with low empathy
Empathy / Social Openness×3
2
Euphoria / Mood Elevation×2
6
Stimulation×1
7
Sensory Enhancement×1
7
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Experience Report Analysis
Erowid
3
Reports
2
Single-substance
2003–2021
Date Range
1
With Age Data
Demographics
Gender Distribution
Too few reports for a chart: gender is known from 3 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?
- Male 3 of 3
Age Distribution
Reports Over Time
References
Data Sources
Cited References
- Drug Users Bible: Yopo
- Erowid: Anadenanthera
- Fuller et al. 1995: Tissue distribution and metabolism of bufotenine
- Health Canada Drug Status Report: Anadenanthera peregrina
- Ott 2001: Pharmañopo-Psychonautics of Bufotenine
- PsychonautWiki: Anadenanthera peregrina
- PsychonautWiki: Bufotenin
- Rodd 2002: Snuff synergy with yopo and Banisteriopsis caapi
- Torres & Repke 2006: Anadenanthera - Visionary Plant of Ancient South America
- Tripsitter: Yopo
- Tripsitter Substack: Yopo