Being an insomniac, I took up the chance to experiment with tranquilizers when my dealer gave me the remnants of a bottle of xylazine he had procured on a previous pharm run from Mexico. On the day of the experiment I had smoked some cannabis hours earlier but no real effects remained with me.
Xylazine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Aliases: Tranq, Tranq dope, Xyl, Xyla
Summary
Xylazine (also known as xyl, xyla, or tranq) is a central nervous system (CNS) depressant substance of the imidazoline class. It is primarily used as an anaesthetic in combination with ketamine or as an emetic (to induce vomiting) in veterinary medicine. Xylazine is often used as a cutting agent for other sedative street drugs, such as ketamine, fentanyl, and others, leading to many medical complications and deaths for drug users. It is not an opioid, so naloxone does not reverse it, though naloxone should still be given when an opioid may be involved.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 5-7.5mg | 10-12.5mg | 15-20mg | 25mg+ |
Light
Common
Strong
Heavy
Sources
Intravenous
Dose ladder — dose.wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Intravenous | 5-10 min | 4-12 hrs | 4-12 hrs |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.
No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder
Combinations
Cross-Check Xylazine with another substanceWritten here from CDC guidance on xylazine; TripSit has no xylazine data. Xylazine is a sedative, not an opioid, so naloxone does not reverse it.
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 1 neutral 1 cautionary visit
I work at a vet clinic and value my future but also am on the look out for free highs that I think carry no risk for me. I only take what will never be noticed and only then when the opportunity arises. I took 10 10mg valium and some phenobarbs (which I didn't know sucked) previously and that was a few months ago.
Xylazine's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Xylazine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "Xylazine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
Xylazine
Unit
mg
Description
Xylazine Source: SubstanceSearch (substancesearch.com) Intravenous dose (mg): threshold 1 · light 5-7.5 · common 10-12.5 · strong 15-20 · heavy 25+ Intravenous duration: onset 5-10m · peak 4-12h · total 4-12h · after-effects 12-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 11.25 mg (Intravenous).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Xylazine? Let us know. Reports are reviewed by moderators — this is not posted publicly.