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XLR-11 Stats & Data

Cannabinoid

PubChem CID 57501498

NPS DataHub

MW329.46

FormulaC21H28FNO

CAS1364933-54-9

IUPAC[1-(5-fluoropentyl)indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone

SMILESFCCCCCn1cc(C(=O)C2C(C)(C)C2(C)C)c2ccccc12

InChIKeyPXLDPUUMIHVLEC-UHFFFAOYSA-N

Cannabinoids; 2020/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2021/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2022/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen

Chemical Class Tetramethylcyclopropanoylindole

Pharmacology

DrugBank

Mechanism of Action

Synthetic indole-derived cannabinoids have become commonly used recreational drugs and continue to be abused despite their adverse consequences. As compounds that were identified early in the epidemic (e.g., naphthoylindoles) have become legally banned, new compounds have appeared on the drug market. Two tetramethylcyclopropyl ketone indoles, UR-144 (1-pentyl-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone and XLR-11 [(1-(5-fluoropentyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)

Metabolism

The knowledge of metabolic profile of synthetic cannabinoids is important for the detection of drugs in urinalysis due to the typical absence or low abundance of parent cannabinoids in human urine. The fungus Cunninghamella elegans has been reported to be a useful tool for metabolism study and thus applicability to synthetic cannabinoid metabolism was examined. In this study, 8-quinolinyl 1-(5-fluoropentyl)-1H-indole-3-carboxylate (5F-PB-22), 8-quinolinyl 1-pentyl-1H-indole-3-carboxylate (PB-22)

Toxicity

PubChem

There have been case reports of acute kidney injury associated with the use of synthetic cannabinoids such as XLR-11. There has also been at least one case of acute cerebral infarction associated with XLR-11 inhalation.

Experience Report Analysis

Erowid

1 Reports

2012–2012 Date Range

1 With Age Data

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Real-World Dose Distribution

62K Doses

From 3 individual dose entries

Read full reports on Erowid →

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