U-47700 Stats & Data
CN(C)C1CCCCC1N(C)C(=O)c1ccc(Cl)c(Cl)c1JGPNMZWFVRQNGU-LSDHHAIUSA-NPharmacology
DrugBankMechanism of Action
/ALTERNATIVE and IN VITRO TESTS/ U-47700 /was evaluated/ for its in vitro binding activity using guinea pig brain at the mu opioid receptor (MOR) and the kappa opioid receptor (KOR). U-47700 had high affinity at the MOR and bound with a KD of 5.3 nM and weakly at the KOR with a KD of 910 nM resulting in a >171x preference for the MOR relative to the KOR. (14) Subsequently these researchers reported U-47700 receptor affinities (IC50s) of 9 and 300 nM, respectively, for the MOR and KORs.
Metabolism
Recently, the number of adverse events, including death, involving novel opioids has continued to increase, providing additional and sustained challenges for forensic and medical communities. Identification of emerging novel opioids can be challenging, compounded by detection windows and unknown metabolic profiles. In this study, human liver microsomes were used for the generation of in vitro metabolic profiles of U-47700 and U-49900. Generated metabolites were analyzed via a SCIEX TripleTOF 560
Receptor Profile
Receptor Actions
Toxicity
PsychonautWikiU-47700 has a high toxicity relative to its dose due to its extreme potency. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also potentially lethal when mixed with depressants like alcohol or benzodiazepines. It is worth noting that U-47700 crystals are particularly corrosive and somewhat caustic to mucous membranes. Careless use may deteriorate the chosen routes of administration so it is important to practice routine maintenance such as soaking the sinus cavity with water prior to and following insufflation.
Effect Profile
Curated + 7 ReportsStrong euphoria and pain relief with mild sedation and itching/nausea
Tolerance & Pharmacokinetics
drugs.wikiNo tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Experience Report Analysis
ErowidDemographics
Gender Distribution
Too few reports for a chart: gender is known from 9 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?
- Not Specified 1 of 9
- Male 8 of 9
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 7 experience reports (7 single-substance Erowid)
Effect Sentiment Distribution
Confidence Distribution
Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.
Too few reports for bars: these effects come from 7 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Positive Effects 1
Adverse Effects 0
Show 1 neutral or unclassified mention
Form / Preparation
Most common forms and preparations, as a share of the 5 reports that give one
Too few reports for bars: these forms come from 5 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
- Powder / Crystals 2 of 5
- Liquid 2 of 5
Legal Status
| Country | Status | Notes |
|---|---|---|
| Austria | illegal | Controlled under SMG (Suchtmittelgesetz) since June 26, 2019. |
| Czech Republic | controlled | Schedule I controlled substance. |
| Sweden | illegal | Classified as a narcotic substance. |
| United Kingdom | controlled | Class A, Schedule 1 substance. |
| United States | controlled | Schedule I since October 2016. Originally temporarily scheduled; now permanently controlled as a synthetic opioid. |
| United States - Florida | controlled | Emergency scheduled at state level. |
| United States - Ohio | controlled | Emergency scheduled at state level. |