Tryptamine Stats & Data
NCCc1cnc2ccccc12APJYDQYYACXCRM-UHFFFAOYSA-NPharmacology
DrugBankMeasured Affinities
Guide to PHARMACOLOGYMeasured binding and functional data for tryptamine, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.
| Target | Action | Measure | Value | Concentration | Species | Source |
|---|---|---|---|---|---|---|
| 5-HT2A receptor Htr2a | Full agonist | pKi | 7.1 | 79.43 nM | Rat | PMID 8114677 |
| 5-HT2B receptor Htr2b | Full agonist | pKi | 7 | 100 nM | Rat | PMID 8450835 |
| 5-HT2B receptor HTR2B | Full agonist | pKi | 7 | 100 nM | Human | PMID 15322733 |
| 5-HT7 receptor HTR7 | Full agonist | pKi | 6.8 | 158.49 nM | Human | PMID 8226867 |
| 5-HT1B receptor HTR1B | Full agonist | pKi | 6.3 | 501.19 nM | Human | PMID 1565658 |
| 5-HT1F receptor HTR1F | Full agonist | pKi | 5.6 | 2,512 nM | Human | PMID 8380639 |
| 5-HT1D receptor HTR1D | Full agonist | pKi | — | — | Human | — |
| 5-HT2A receptor HTR2A | Full agonist | pKi | — | — | Human | — |
| 5-HT2C receptor HTR2C | Full agonist | pKi | — | — | Human | — |
| 5-HT6 receptor Htr6 | Full agonist | pKi | — | — | Rat | — |
| 5-HT7 receptor Htr7 | Full agonist | pKi | — | — | Rat | PMID 8394362 |
| 5-ht1e receptor HTR1E | Full agonist | pKi | — | — | Human | — |
Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.
Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.
Effect Profile
CuratedStrong visuals with mild headspace, auditory effects, and body load
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.