so i took 10x150mg of tramadol. Im also on 250mg of meth (orally) & i didn't know there was any interaction cus cba to research it.... I've Took 3x150mg of meth several times and nothing bad happened just felt like a speedball but pretty weak....
Tramadol
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: Tram, Tramal, Ultram
Summary
Tramadol is a quasi-narcotic analgesic used in the treatment of moderate to severe pain. It is a synthetic analog of codeine, but has a low binding affinity to the mu-opioid receptors. It has been prescribed off-label for the treatment of diabetic neuropathy and restless leg syndrome.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-100mg | 100-250mg | 250-300mg | 300mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — PsychonautWiki
⚠ above 250–300 mg (single dose) oral
Seizure risk rises
“Tramadol lowers seizure threshold; risk rises with higher single doses (>250-300 mg), rapid redosing, co-use of stimulants or other seizure-threshold-lowering medicines (e.g., bupropion, many antidepressants), history of seizures, or electrolyte abnormalities.” — dose.wiki
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 12-60 min | 30-60 min | 2-6 hrs | 2-4 hrs | 6-14 hrs |
Opioid MME Calculator
⚠ Citation & Disclaimer:
Conversion factors sourced from the
NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025),
the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain,
and the MDCalc MME Calculator.
These are approximate equianalgesic ratios for educational reference only.
Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration.
This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
mg
50
mg
Tramadol
≈
—
mg
Morphine
| Substance | Equivalent Dose | MME Factor |
|---|
⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
297 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 247 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
7.7
Intense
8/10
Strong euphoria, pain relief, and sedation with strong itching/nausea
Euphoria / Warmth
×3
10
physical euphoria
euphoria
cognitive euphoria
overall feeling of contentedness
Analgesia
×2
8
pain relief
Sedation / Relaxation
×1
8
sedation
drowsiness
Itching / Nausea
×1
10
itching
nausea
vomiting
constipation
urinary retention
Based on reports from:
Tolerance
Build-up
develops over weeks of regular use; serotonergic effects may not show the same tolerance curve
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Other opioids
Effects
Aggregated from 247 single-substance Erowid and 50 Bluelight experience reports; 123 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 51
50.0% (95% interval 37 to 63 percent)
84%
45.5% (95% interval 40 to 51 percent)
90%
29.0% (95% interval 24 to 34 percent)
86%
26.6% (95% interval 22 to 32 percent)
82%
22.0% (95% interval 13 to 35 percent)
86%
18.8% (95% interval 15 to 24 percent)
86%
18.1% (95% interval 14 to 23 percent)
85%
16.0% (95% interval 8 to 28 percent)
79%
14.0% (95% interval 7 to 26 percent)
86%
14.0% (95% interval 7 to 26 percent)
86%
13.4% (95% interval 10 to 18 percent)
84%
13.2% (95% interval 10 to 17 percent)
92%
12.0% (95% interval 6 to 24 percent)
87%
12.0% (95% interval 6 to 24 percent)
75%
12.0% (95% interval 6 to 24 percent)
87%
10.0% (95% interval 4 to 21 percent)
80%
10.0% (95% interval 4 to 21 percent)
80%
10.0% (95% interval 4 to 21 percent)
81%
8.0% (95% interval 3 to 19 percent)
80%
8.0% (95% interval 3 to 19 percent)
79%
Show 31 more positive effects
8.0% (95% interval 3 to 19 percent)
86%
6.4% (95% interval 4 to 10 percent)
82%
6.0% (95% interval 2 to 16 percent)
85%
5.3% (95% interval 3 to 9 percent)
–
4.9% (95% interval 3 to 8 percent)
–
4.3% (95% interval 3 to 7 percent)
83%
4.0% (95% interval 1 to 14 percent)
82%
4.0% (95% interval 1 to 14 percent)
82%
4.0% (95% interval 1 to 14 percent)
82%
4.0% (95% interval 1 to 14 percent)
92%
4.0% (95% interval 1 to 14 percent)
80%
4.0% (95% interval 1 to 14 percent)
85%
4.0% (95% interval 1 to 14 percent)
88%
3.0% (95% interval 2 to 6 percent)
80%
2.7% (95% interval 1 to 5 percent)
85%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
70%
2.0% (95% interval 0 to 10 percent)
95%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
75%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
75%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
75%
2.0% (95% interval 0 to 10 percent)
75%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
90%
Adverse Effects 42
27.6% (95% interval 23 to 33 percent)
84%
20.6% (95% interval 16 to 26 percent)
81%
20.0% (95% interval 11 to 33 percent)
87%
14.6% (95% interval 11 to 20 percent)
–
12.8% (95% interval 10 to 17 percent)
81%
12.0% (95% interval 6 to 24 percent)
81%
12.0% (95% interval 6 to 24 percent)
77%
8.8% (95% interval 6 to 12 percent)
86%
8.7% (95% interval 6 to 12 percent)
82%
8.0% (95% interval 3 to 19 percent)
76%
8.0% (95% interval 3 to 19 percent)
88%
6.0% (95% interval 2 to 16 percent)
80%
6.0% (95% interval 2 to 16 percent)
88%
5.4% (95% interval 3 to 9 percent)
79%
4.0% (95% interval 1 to 14 percent)
78%
4.0% (95% interval 1 to 14 percent)
80%
4.0% (95% interval 1 to 14 percent)
78%
4.0% (95% interval 1 to 14 percent)
70%
4.0% (95% interval 1 to 14 percent)
80%
4.0% (95% interval 1 to 14 percent)
75%
Show 22 more adverse effects
4.0% (95% interval 1 to 14 percent)
65%
4.0% (95% interval 1 to 14 percent)
80%
4.0% (95% interval 1 to 14 percent)
80%
4.0% (95% interval 1 to 14 percent)
85%
4.0% (95% interval 1 to 14 percent)
88%
4.0% (95% interval 2 to 7 percent)
–
2.8% (95% interval 1 to 6 percent)
–
2.4% (95% interval 1 to 5 percent)
–
2.0% (95% interval 0 to 10 percent)
75%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
70%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
90%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
80%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
85%
2.0% (95% interval 0 to 10 percent)
90%
Also reported in combinations. In the 123 Tramadol reports where another drug was taken too, 25 (20.3%) mention hospital, emergency services or an overdose, 18 (14.6%) a seizure and 2 (1.6%) psychosis. In the 247 single-substance reports: 10.9%, 14.6% and 0.4%. These are not in the figures above: they cannot be put down to Tramadol alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check Tramadol with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Reddit 1 report 1 neutral visit
Erowid 8 reports 2 positive 2 neutral 4 cautionary visit
First of all I have been experimenting with many substances this summer and when one of my friends told me about painkillers it sounded interesting to I wanted to try it. I had some hydrocodone and instantly fell in love with the immense Chill feeling that painkillers gave me.
About two years ago I came down with a mystery illness while visiting a friend on vacation. It caused severe muscle aches, among other symptoms. It was a very mysterious illness that lasted for at least three weeks.
The first time I tried tramadol I took 4 and it was an exact copy of a hydrocodone high, maybe even better. Snorting 1 or 2 ultrams can also be fun but not that much fun because it seems to lower my threshold of pain specifically in my nose, so when I snort a big line, Ill feel it and it'll sting and Ill get high, bu...
This was my first time experiencing with opiates, or, actually, any downer drugs. I have been around narcotics for a few years, but my experience was limited to the amphetamine family, cocaine and 25i-nBOME.
Long Term User of Tramadol Male, 62, 240 lbs Drug: Generic Tramadol 50mg & 100mg (Both without acetaminophen) My use of tramadol began about two years ago. My first script was only 30 pills. But this was by far the best opiate I ever had. In the past, I have had just about every opiate short of heroine and morphine.
I want to preface this by pointing out that my experience with this substance was very different from most. I ran into side effects that I had never even considered a possibility until they were too strong to deny.
[Erowid Note: The doses described in this report are potentially life threatening. The amount taken is beyond a heavy dose and could pose serious health risks or result in unwanted, extreme effects. Doses such as this have been known to cause hospitalizations and/or deaths.
It is with deep regret that I detail my account with tramadol. It has been a three year journey for me with Ultrams. It started out as a means to kill pain after a surgical GYN procedure, and escalated into full fledged addiction that is no longer fun by any stretch of the vivid imagination.
Bluelight 8 threads 2 positive 5 neutral 1 cautionary visit
Tramadol 100mg - First Time - Enjoyable Night I consumed 2 50mg Tramadols at about 12:30am. I ate a little food before i dosed to avoid any nausea. I am not on any medications and I consumed no other drugs over the course of the evening. I also have not taken any opiates in over 2 years. I am 20/m 130lbs 12:30- Dosed.
ultracet 1st time didnt go to school today cuz i was feeling sick, as i was looking for some vitamin c to speed up the healing process i stumbled across an old prescription i had that was given to me after my ear surgery. read the label and found out its ultracet.
Im relatively new to opiates/opiods and Ive tried Hydrocodone 7.5/650 but it was a short lived high. As of latly I was prescribed 50 mg Tramadol and in contrast to what a majority of people say, it was/is AMAZING. I took one 50 mg and another 30 minutes later.
this trip report took place last night from like 11:30pm to about 3:00am. i got the pills from my friend who didnt even know what they were. i have never tried them before but i have read trip reports. ------------- about an hour or so ago - popped 150mg of tramadol (Ultram) hci (three pills so far).
The night before i smoked my last bowl of cannabis, not really a big deal for me as I use it to enhance sexual desires and increase my appetite. This morning my grandmother gave me 17 tramadol and insisted that I go easy, but as ignorant as I am to following other's instructions I ended up taking all of them not at onc...
Hey there people, Well, I've been meaning to try these tramadol tablets a friend gave me a few weeks ago. Been going through heavy midterms, exams and finals, and postponed the experience. Previous drug experience: A lot. an opiate virgin, though.
Tramadol I have been using tramadol for about 2 years now. But I am not addicted and surprisingly the tolerance level has never changed. Ive always done 250mg, as 1 strip of 50mg tablets [10 tablets] is only a dollar here, and relatively easy to obtain.
First of all, this report is based on a huge dose of tramadol (5 times the maximum therapeutic dose recommended). Please don't try it if you don't have a very high tolerance to this drug or have a history of seizures.Takin' an anti-convulsant (benzodiazepines) prior these doses of tramadol is extremely reccommend.
Pill Identifiers
17
known pill identifiers on record — view imprints, colors, shapes, and images
→
Tramadol's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Tramadol, but its built-in data can be thinner than ours. Importing this file adds a separate "Tramadol (Substance Search)" custom substance with our dose ranges and durations, so you can log against whichever you prefer. It leaves tolerance out on purpose, for the reason given under Tolerance above.
⬇ Download import file
Import this file as custom substances
and you get "Tramadol (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Tramadol? Let us know. Reports are reviewed by moderators — this is not posted publicly.