Nice First Experience With Opioids First a few infos concerning myself and drugs: About me: I'm female, 5'8'', 130 lbs. I don't use drugs (including alcohol/cigarettes) too often and I'm not someone who gets addicted easily (never happened to me in my life).
Tilidine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
Aliases: Tilidin, Valoron, Valtran, Tilidate
Summary
Synthetic opioid, used mainly for treatment of moderate to severe pain. In some countries it's mixed with Naloxone to lower the abuse liability. Though in some only Tilidine.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-100mg | 100-200mg | 200mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 10-20 min | 3-6 hrs | 3-6 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Combinations
Cross-Check Tilidine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 neutral visit
Tilidine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Tilidine, but its built-in data can be thinner than ours. Importing this file adds a separate "Tilidine (Substance Search)" custom substance with our dose ranges and durations, so you can log against whichever you prefer. It leaves tolerance out on purpose, for the reason given under Tolerance above.
⬇ Download import file
Import this file as custom substances
and you get "Tilidine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Tilidine? Let us know. Reports are reviewed by moderators — this is not posted publicly.