The country I live has Stablon (tianeptine) available without prescription from pharmacies. After some research, I decided to try it out. First, I took 3 tabs (12,5mg each), max. daily dosage, and noticed a slight headache after 30 mins, which is average onset time.
Tianeptine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Zaza, Coaxil, Stablon, Tatinol, Pegasus
Summary
Tianeptine (trade names Stablon and Coaxil) is an atypical antidepressant. While primarily a prescription drug, it is sometimes used in high doses for recreational opioid effects. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~99% | 6-12mg | 12-35mg | 35-100mg | 100mg+ |
Light
Common
Strong
Heavy
Sources
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 15-30 min | 60-90 min | 30-60 min | 2-3 hrs |
| Intravenous | <1-1 min | 0-36 sec | 10-30 min | 1-2 hrs | 4-6 hrs |
Effect Profile
9 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.0
Moderate+
5/10
Moderate euphoria with moderate itching/nausea, mild sedation and pain relief
Euphoria / Warmth
×3
6
physical euphoria
cognitive euphoria
Analgesia
×2
4
analgesia
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Effects
Aggregated from 9 single-substance Erowid experience reports; 8 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 9 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 3
5 of 9
–
4 of 9
–
3 of 9
–
Adverse Effects 0
Also reported in combinations. In the 8 Tianeptine reports where another drug was taken too, 0 mention hospital, emergency services or an overdose, 0 a seizure and 1 psychosis (too few reports for percentages). In the 9 single-substance reports: 0, 0 and 0. These are not in the figures above: they cannot be put down to Tianeptine alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check Tianeptine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 5 neutral 3 cautionary visit
I'm a big fan of opiates. Ever since I tried some hydrocodone about seven years ago, I've been enjoying experimenting with different opiates, and spending considerable time taking them.
This experience was mostly pleasant. To provide a baseline, I started off the night with one drink but otherwise was completely sober and have not used any other drugs or medications in months. I was curious to try Tianeptine because it has been banned in my home state, which of course adds an appeal for some people.
Tianeptine Is Weird I've gotten my hands on some tianeptine sulfate and tianeptine sodium this last month. There is quite a difference between the two in terms of the acute side effects. This is about my experience with tianeptine sodium.
BACKGROUND: I have a long and torrid history with antidepressants. I spent 9 years on SSRI's, SNRI's, atypicals, tricyclics and even Risperdal in a vain attempt to treat depression. No such luck.
I've been taking Tianeptine now for about 5 months, with a break of about one month after the second. I've taken Fluoxetine (Prozac), Buspirone (Buspar), and (Buproprion) Wellbutrin, all of which helped in varying degrees but had side-effects that outweighed the benefit for me.
I wanted to provide some insight for the benefit of others due to the surprising scarcity of information regarding this drug -- so I appreciate anyone taking the time to read my thoughts on the matter.
Ill try to make this long story short. After 2 years of a barrage of anti-depressants totally fucked up my psyche permanently, I took something I did occasionally for fun (hydrocodone) and made it a daily habit. Got off, went through withdrawals. Months later, me and girlfriend back on.
Bluelight 2 threads 2 neutral visit
Ok, there's not a ton of information out there on this substance so I figured that I would put together my experience with it as it's a very particular substance with unique properties and definite recreational potential.
I've done most of the opioids and other drugs. I read about Tianeptine on BL and decided to order some. Let me say this shit is pretty damn good, and cheap compared to other drugs. I came home from work tonight and the package was waiting in the mail.
Tianeptine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Tianeptine, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "Tianeptine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Duration (reference)
Tianeptine: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Intravenous duration: onset <1-1m · come-up 0-36s · peak 10-30m · offset 1-2h · total 4-6h · after-effects 6-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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