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Thebaine Stats & Data

Opioid

PubChem CID 5324289

NPS DataHub

MW311.38

FormulaC19H21NO3

CAS115-37-7

IUPAC6,7,8,14-Tetradehydro-4,5a-epoxy-3,6-dimethoxy-17-methylmorphinan

SMILESCOC1=CC=C2C3N(C)CCC22C1Oc1c(OC)ccc(C3)c12

InChIKeyFQXXSQDCDRQNQE-VMDGZTHMSA-N

Chemical Class Morphinan

Measured Affinities

Guide to PHARMACOLOGY

Measured binding and functional data for thebaine, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

Target	Action	Measure	Value	Concentration	Species	Source
μ receptor OPRM1	Partial agonist	pEC50	5.25	5,623 nM	Human	PMID 17616524

Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

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