Tfmpp Stats & Data
KKIMDKMETPPURN-UHFFFAOYSA-NPharmacology
DrugBankMetabolism
1-(3-Trifluoromethylphenyl)piperazine has known human metabolites that include HO-TFMPP.
Measured Affinities
Guide to PHARMACOLOGYMeasured binding and functional data for TFMPP, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.
| Target | Action | Measure | Value | Concentration | Species | Source |
|---|---|---|---|---|---|---|
| 5-HT2A receptor HTR2A | Full agonist | pKi | 7.5 | 31.62 nM | Human | PMID 15322733 |
| 5-HT2B receptor HTR2B | Full agonist | pKi | 7.2 | 63.1 nM | Human | PMID 15322733 |
| 5-HT2B receptor Htr2b | Full agonist | pKi | 7.1 | 79.43 nM | Rat | PMID 8450835 |
| 5-HT6 receptor HTR6 | Full agonist | pKi | 6.4 | 398.11 nM | Human | PMID 8522988 |
| 5-HT6 receptor Htr6 | Full agonist | pKi | 6.3 | 501.19 nM | Rat | PMID 7680751 |
| 5-HT7 receptor Htr7 | Antagonist | pKi | 6.3 | 501.19 nM | Mouse | PMID 8394987 |
| 5-HT1F receptor HTR1F | Full agonist | pKi | 6 | 1,000 nM | Human | PMID 8380639 |
| 5-HT5A receptor Htr5a | Full agonist | pKi | 5.6 | 2,512 nM | Mouse | PMID 8450829 |
| 5-HT1B receptor HTR1B | Full agonist | pKi | — | — | Human | — |
| 5-HT1D receptor HTR1D | Full agonist | pKi | — | — | Human | — |
| 5-HT2C receptor HTR2C | Full agonist | pKi | — | — | Human | — |
| 5-HT7 receptor Htr7 | Full agonist | pKi | — | — | Rat | PMID 8394362 |
| 5-ht1e receptor HTR1E | Full agonist | pKi | — | — | Human | — |
Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.
Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.
Effect Profile
Curated + 19 ReportsStrong euphoria and anxiety/jitters with moderate focus and stimulation
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Experience Report Analysis
ErowidDemographics
Gender Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 19 experience reports (19 Erowid)
Effect Sentiment Distribution
Confidence Distribution
Positive Effects 6
Adverse Effects 4
Dosage Distribution
Dose distribution from experience reports
Common Combinations
Most co-occurring substances in experience reports
Form / Preparation
Most common forms and preparations reported
Body-Weight Dosing
Dose relative to body weight from reports with weight data
Redose Patterns
Redosing behavior across 13 reports